中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
3期
30-32
,共3页
孕妇%高凝状态%弥漫性血管内凝血%纤维蛋白原%D-二聚体
孕婦%高凝狀態%瀰漫性血管內凝血%纖維蛋白原%D-二聚體
잉부%고응상태%미만성혈관내응혈%섬유단백원%D-이취체
Factors Ⅶ、Ⅷ、Ⅹ%AT-Ⅲ%Fibrinogen%D-Dimer%DIC
目的探讨孕妇高凝状态Pre-DIC、DIC相关检测指标的临床意义.方法应用Clauss法、凝固法、免疫散射比浊法、发色底物法,分别检测孕妇与健康非孕育龄妇女的Fib、Ⅶ、Ⅷ、Ⅹ、AT-Ⅲ和D-D水平并结合DIC病例进行临床分析.结果孕妇组(n=40)Fib为(4.41±0.72)g/L;Ⅶ(160.30±29.17)%;Ⅷ(143.87±50.30)%;Ⅹ(120.17±18.47)%;AT-Ⅲ(81.28±10.86)%;D-D为(1.56±0.98)mg/L.对照组(n=20):Fib为(3.05±0.60)g/L;Ⅶ(97.80±11.93)%;Ⅷ(112.00±25.69)%;Ⅹ(93.20±9.31)%;AT-Ⅲ(105.00±7.84)%;D-D为(0.23±0.08)mg、L.孕妇组各项指标与对照组比较差异显著(P<0.01;P<0.05).6例产前孕妇Pre-DIC相关指标检测结果,4例PT在正常参考范围内(11.5～14.5s),2例分别为10.8、16.9s;6例APTT均在正常参考范围内(28.0～43.5s);4例Fib分别为5.16、5.13、5.10、5.70 g/L,2例分别为3.95、2.86 g/L;D-D均>5.00 mg/L.10例DIC产妇PT均延长,平均33.98s(15-120s);APTT平均78.19s(31.6～180 s),其中4例在正常参考范围内,分别为40.0、41.0、33.9、31.6 s;Fib均<1.48 g/L;D-D平均18.39 mg、L(6.24～49.6 mg/L).结论 Fib与D-D为孕妇高凝状态Pre-DIC/DIC检测的敏感、实用指标;PT、APTY仅能作DIC检测指标.
目的探討孕婦高凝狀態Pre-DIC、DIC相關檢測指標的臨床意義.方法應用Clauss法、凝固法、免疫散射比濁法、髮色底物法,分彆檢測孕婦與健康非孕育齡婦女的Fib、Ⅶ、Ⅷ、Ⅹ、AT-Ⅲ和D-D水平併結閤DIC病例進行臨床分析.結果孕婦組(n=40)Fib為(4.41±0.72)g/L;Ⅶ(160.30±29.17)%;Ⅷ(143.87±50.30)%;Ⅹ(120.17±18.47)%;AT-Ⅲ(81.28±10.86)%;D-D為(1.56±0.98)mg/L.對照組(n=20):Fib為(3.05±0.60)g/L;Ⅶ(97.80±11.93)%;Ⅷ(112.00±25.69)%;Ⅹ(93.20±9.31)%;AT-Ⅲ(105.00±7.84)%;D-D為(0.23±0.08)mg、L.孕婦組各項指標與對照組比較差異顯著(P<0.01;P<0.05).6例產前孕婦Pre-DIC相關指標檢測結果,4例PT在正常參攷範圍內(11.5～14.5s),2例分彆為10.8、16.9s;6例APTT均在正常參攷範圍內(28.0～43.5s);4例Fib分彆為5.16、5.13、5.10、5.70 g/L,2例分彆為3.95、2.86 g/L;D-D均>5.00 mg/L.10例DIC產婦PT均延長,平均33.98s(15-120s);APTT平均78.19s(31.6～180 s),其中4例在正常參攷範圍內,分彆為40.0、41.0、33.9、31.6 s;Fib均<1.48 g/L;D-D平均18.39 mg、L(6.24～49.6 mg/L).結論 Fib與D-D為孕婦高凝狀態Pre-DIC/DIC檢測的敏感、實用指標;PT、APTY僅能作DIC檢測指標.
목적탐토잉부고응상태Pre-DIC、DIC상관검측지표적림상의의.방법응용Clauss법、응고법、면역산사비탁법、발색저물법,분별검측잉부여건강비잉육령부녀적Fib、Ⅶ、Ⅷ、Ⅹ、AT-Ⅲ화D-D수평병결합DIC병례진행림상분석.결과잉부조(n=40)Fib위(4.41±0.72)g/L;Ⅶ(160.30±29.17)%;Ⅷ(143.87±50.30)%;Ⅹ(120.17±18.47)%;AT-Ⅲ(81.28±10.86)%;D-D위(1.56±0.98)mg/L.대조조(n=20):Fib위(3.05±0.60)g/L;Ⅶ(97.80±11.93)%;Ⅷ(112.00±25.69)%;Ⅹ(93.20±9.31)%;AT-Ⅲ(105.00±7.84)%;D-D위(0.23±0.08)mg、L.잉부조각항지표여대조조비교차이현저(P<0.01;P<0.05).6례산전잉부Pre-DIC상관지표검측결과,4례PT재정상삼고범위내(11.5～14.5s),2례분별위10.8、16.9s;6례APTT균재정상삼고범위내(28.0～43.5s);4례Fib분별위5.16、5.13、5.10、5.70 g/L,2례분별위3.95、2.86 g/L;D-D균>5.00 mg/L.10례DIC산부PT균연장,평균33.98s(15-120s);APTT평균78.19s(31.6～180 s),기중4례재정상삼고범위내,분별위40.0、41.0、33.9、31.6 s;Fib균<1.48 g/L;D-D평균18.39 mg、L(6.24～49.6 mg/L).결론 Fib여D-D위잉부고응상태Pre-DIC/DIC검측적민감、실용지표;PT、APTY부능작DIC검측지표.
Objective To explore the clinical meaning of the related examination in Pre-DIC/DIC in pregnant woman. Methods Fib、Ⅶ、Ⅷ、Ⅹ、AT-Ⅲ、D-Dimer in pregnant were detected with clauss method、so-lidity method、immunoturbidimetric methodrespect and chromozym method, respectively. Result In pregnant woman group(n=40),the level of correlating factors,including Fib、Ⅶ、Ⅷ、Ⅹ、AT-Ⅲ and D-Dimer,were 4.41g/L±0.72 g/L、160.30%±29.17 %、143.87%±50.30%、120.17%±18.47 %、81.28%±10. 86%、1.56 mg/L±0.98 mg/L, respectively and 3.05 g/L±0.60 g/L、97.80%±11.93 %、112.00%±25.69 %、93.20%±9.31%、105.00%±7.84%、0. 23 mg/L±0.08 mg/L in control group (n=20), re-spectively. Results Of the related examination in pregnant woman group was much higher than that in Control group (P<0.01 or P<0.05) PT by two exceptions and APTT in Pre-DIC in pregnant woman (6 Cases) were all normal. Fib and D-Dimer density were all over and above 5 g/L and 6 mg/L, respectively. Conclusion Fib and D-Dimer was a sensitive indication for Pre-DIC/DIC.
