晚期糖基化终产物诱导人脐静脉内皮细胞ERM蛋白磷酸化的机制
만기당기화종산물유도인제정맥내피세포ERM단백린산화적궤제
Mechanism of advanced glycation end products-stimulated phosphorylation of ERM protein in human umbilical vein endothelial cells
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2010年 1期 19-21 ,共3页

    王占华%郭晓华%陈波%李强%王吉萍%朱平%王陵军%吴炜%黄巧冰

    왕점화%곽효화%진파%리강%왕길평%주평%왕릉군%오위%황교빙

    糖基化终末产物%晚期%ERM蛋白%丝裂原激活蛋白激酶%Rho激酶 糖基化終末產物%晚期%ERM蛋白%絲裂原激活蛋白激酶%Rho激酶
    당기화종말산물%만기%ERM단백%사렬원격활단백격매%Rho격매
    Glycation end products%advanced%Ezrin/radixin/moesin%Mitogen-activated protein kinase%Rho kinase
    采用免疫荧光细胞化学和Western印迹法,探讨晚期糖基化终产物(AGE)对人脐静脉内皮细胞的ERM(ezrin/radixint/moesin)蛋白磷酸化水平和定位的影响及其机制.AGE以时间和剂量依赖性地增加ERM蛋白磷酸化水平(均P<0.05),并促进其转位至胞浆内.AGE通过与其受体结合刺激ERM蛋白的磷酸化,Rho激酶及p38丝裂原活化蛋白激酶通路参与了此过程.
    채용면역형광세포화학화Western인적법,탐토만기당기화종산물(AGE)대인제정맥내피세포적ERM(ezrin/radixint/moesin)단백린산화수평화정위적영향급기궤제.AGE이시간화제량의뢰성지증가ERM단백린산화수평(균P<0.05),병촉진기전위지포장내.AGE통과여기수체결합자격ERM단백적린산화,Rho격매급p38사렬원활화단백격매통로삼여료차과정.
    The effects of advanced glycation end products(AGE)on phosphorylation of ezrin/radixin/ moesin(ERM)protein in human umbilical vein endothelial ceils were detected by immunofluorescence cytochemistry and its mechanism was explored.AGE stimulated the phosphorylation of ERM protein in dose-and time-dependent manners(all P<0.05),which was involved in AGE receptor,Rho kinase,and p38 mitogen-activated protein kinase pathways.
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