中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2008年
5期
318-322
,共5页
沈骏%蔡青%冉志华%张尧%周笑甜%殷洪敏%萧树东
瀋駿%蔡青%冉誌華%張堯%週笑甜%慇洪敏%蕭樹東
침준%채청%염지화%장요%주소첨%은홍민%소수동
克罗恩病%结肠炎,溃疡性%代谢%蛋白质%脂
剋囉恩病%結腸炎,潰瘍性%代謝%蛋白質%脂
극라은병%결장염,궤양성%대사%단백질%지
Crohn disease%Colitis,ulcerative%Metabolism%Protein%Lipid
目的 比较炎症性肠病患者及正常对照者之间蛋白质和脂代谢的差异,研究这些差异与疾病活动性及病变部位的关系.方法 回顾性研究1995至2007年溃疡性结肠炎(UC)195例、克罗恩病(CD)76例及正常对照者97名的蛋白质和脂代谢资料.同时评价临床疾病活动指数,红细胞沉降率(ESR)和C-反应蛋白(CRP)水平.性别分层分析蛋白质和脂代谢指标的改变,同时分析蛋白质和脂代谢的改变与疾病活动性及病变部位的关系.结果 UC患者的ESR与血清白球比呈负线性相关(β=-0.521,P＜0.01),与α2-球蛋白呈正线性相关(β=0.319,P＜0.01);CD患者血清球蛋白与ESR(β=0.558,P＜0.01)以及cRP(β=0.424,=P0.01)呈正线性相关.UC患者间因病变部位不同,血清白球比、白蛋白和总胆固醇水平存在显著差异,其中直乙结肠炎患者该三项显著高予其他类型的UC患者(P值分别=0.003、0.005、0.038).CD患者间亦因病变部位不同,血清球蛋白水平存在显著差异,仅累及结肠者的血清球蛋白水平显著高于单纯小肠受累者(P=0.029).结论 UC患者血清白球比和α2-球蛋白的异常程度可作为炎症活动性的预测因素;CD患者血清球蛋白增高预示疾病严重程度活动性增加,累及小肠的CD患者相对仅累及结肠的CD患者而言存在更为严重的营养缺失.
目的 比較炎癥性腸病患者及正常對照者之間蛋白質和脂代謝的差異,研究這些差異與疾病活動性及病變部位的關繫.方法 迴顧性研究1995至2007年潰瘍性結腸炎(UC)195例、剋囉恩病(CD)76例及正常對照者97名的蛋白質和脂代謝資料.同時評價臨床疾病活動指數,紅細胞沉降率(ESR)和C-反應蛋白(CRP)水平.性彆分層分析蛋白質和脂代謝指標的改變,同時分析蛋白質和脂代謝的改變與疾病活動性及病變部位的關繫.結果 UC患者的ESR與血清白毬比呈負線性相關(β=-0.521,P＜0.01),與α2-毬蛋白呈正線性相關(β=0.319,P＜0.01);CD患者血清毬蛋白與ESR(β=0.558,P＜0.01)以及cRP(β=0.424,=P0.01)呈正線性相關.UC患者間因病變部位不同,血清白毬比、白蛋白和總膽固醇水平存在顯著差異,其中直乙結腸炎患者該三項顯著高予其他類型的UC患者(P值分彆=0.003、0.005、0.038).CD患者間亦因病變部位不同,血清毬蛋白水平存在顯著差異,僅纍及結腸者的血清毬蛋白水平顯著高于單純小腸受纍者(P=0.029).結論 UC患者血清白毬比和α2-毬蛋白的異常程度可作為炎癥活動性的預測因素;CD患者血清毬蛋白增高預示疾病嚴重程度活動性增加,纍及小腸的CD患者相對僅纍及結腸的CD患者而言存在更為嚴重的營養缺失.
목적 비교염증성장병환자급정상대조자지간단백질화지대사적차이,연구저사차이여질병활동성급병변부위적관계.방법 회고성연구1995지2007년궤양성결장염(UC)195례、극라은병(CD)76례급정상대조자97명적단백질화지대사자료.동시평개림상질병활동지수,홍세포침강솔(ESR)화C-반응단백(CRP)수평.성별분층분석단백질화지대사지표적개변,동시분석단백질화지대사적개변여질병활동성급병변부위적관계.결과 UC환자적ESR여혈청백구비정부선성상관(β=-0.521,P＜0.01),여α2-구단백정정선성상관(β=0.319,P＜0.01);CD환자혈청구단백여ESR(β=0.558,P＜0.01)이급cRP(β=0.424,=P0.01)정정선성상관.UC환자간인병변부위불동,혈청백구비、백단백화총담고순수평존재현저차이,기중직을결장염환자해삼항현저고여기타류형적UC환자(P치분별=0.003、0.005、0.038).CD환자간역인병변부위불동,혈청구단백수평존재현저차이,부루급결장자적혈청구단백수평현저고우단순소장수루자(P=0.029).결론 UC환자혈청백구비화α2-구단백적이상정도가작위염증활동성적예측인소;CD환자혈청구단백증고예시질병엄중정도활동성증가,루급소장적CD환자상대부루급결장적CD환자이언존재경위엄중적영양결실.
Objective To compare the difference of protein and lipid metabolism between patients with inflammatory bowel disease and healthy controls,and to investigate the association of these changes with disease activity and location of the lessions.Methods The retrospective cohort study was carried out.The data of protein and lipid metabolisms collected from 195 patients with ulcerative colitis,76patients with Crohn's disease and 97 healthy controls during 1995 to 2007 were analyzed.Disease activity were evaluated using simple clinieal colitis activity index and simple index of Crohn's disease activity.The erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)were measured.Results Serum levels of ESR in patients with ulcerative colitis were negatively linear correlated with serum levels of albumin/globulin ratio(β=-0.521,P＜0.01)and positively linear correlated with serum levels of α2globulin(β=0.319,P＜0.01).Serum levels of globulin in patients with Crohn's disease were positively linear correlated with serum levels of ESR(β=0.558,P＜0.01)and CRP(β=0.424,P=0.01).In ulcerative colitis,serum levels of albumin/globulin ratio,albumin and total cholesterol were significantly higher in patients with proctosigmoiditis than those in patients with lesions at other locus(P=0.003,0.005,0.038,respectively).In Crohn's disease,serum level of globulin was significantly higher in patients with lesions only at colon than that in patients with lesions only at small bowel(P=0.029).Conclusions Serum levels of albumin/globulin ratio and α2-globulin can be predictors of inflammatory activity in patients with ulcerative colitis.The increasing serum globulin may predict the progression of disease activity in patients with Crohn's disease.The nutritional deficiency is more critical in patiens with small bowel involvement than those with colon involvement.
