CAJ | 학술논문

目的：了解流行性乙型脑炎（乙脑）患者体内干扰素（IFN）水平的变化。方法：采用细胞病变抑制法（CPE）检测51例乙脑患者血清及脑脊液（CSF）中的IFN水平。结果：（1）急性期血清及CSF中的IFN水平均显著升高，恢复期显著下降，但仍明显高于正常对照；CSF中的含量高于血液，并与病情的严重程度关系密切。（2）采用IFN肌肉注射治疗的患者用药后血清中IFN升高，但CSF中IFN水平未见升高，而且临床主要症状及体征改善与未用IFN组无显著差异。结论 (1)IFN参与了乙型脑炎的发病过程。(2)IFN治疗并不能提高疗效，临床上不易贸然使用，需寻找其它更为有效的抗病毒治疗方法。
목적：료해류행성을형뇌염（을뇌）환자체내간우소（IFN）수평적변화。방법：채용세포병변억제법（CPE）검측51례을뇌환자혈청급뇌척액（CSF）중적IFN수평。결과：（1）급성기혈청급CSF중적IFN수평균현저승고，회복기현저하강，단잉명현고우정상대조；CSF중적함량고우혈액，병여병정적엄중정도관계밀절。（2）채용IFN기육주사치료적환자용약후혈청중IFN승고，단CSF중IFN수평미견승고，이차림상주요증상급체정개선여미용IFN조무현저차이。결론 (1)IFN삼여료을형뇌염적발병과정。(2)IFN치료병불능제고료효，림상상불역무연사용，수심조기타경위유효적항병독치료방법。
Objective　To investigate the change of interferon(IFN) level in Japanese B encephalitis patients.Method　Cytopathic effect inhibition assay was used to measure IFN level in the serum and cerebrospinal fluid(CSF) of 51 cases of JBE.Results　(1)In acute phase,IFN levels increased significantly both in serum and CSF,and decreased significantly in recover phase,but were still higher than those in the healthy control subjects.The levels of IFN in CSF were significantly higher than those in serum,and were highly associated with the severity of the disease.(2)After intramuscalar injected with IFN,the levels of IFN increased significantly in serum,but did not increase in CSF at all.There was no significant improvement of clinical symptoms and signs compared with the group that did not have the administration of IFN.Conclusions　(1)IFN plays one of the important roles in Japanese B encephalitis.(2)There are no obvious effects in IFN therapy.So we must search for other antiviral agents.