中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2008年
28期
37-39
,共3页
胡礼仪%张高明%李志沭%陈慧芹%杨莉%许森林%葛林
鬍禮儀%張高明%李誌沭%陳慧芹%楊莉%許森林%葛林
호례의%장고명%리지술%진혜근%양리%허삼림%갈림
淀粉样蛋白%白细胞介素18%糖尿病%2型%大血管病变
澱粉樣蛋白%白細胞介素18%糖尿病%2型%大血管病變
정분양단백%백세포개소18%당뇨병%2형%대혈관병변
Amyloid%Interleukin-18%Diabetes mellitus,type 2%Macrovascular lesion
目的 探讨血清淀粉样蛋白A(SAA)、白细胞介素(IL)-18与2型糖尿病(T2DM)及其合并大血管病变的关系.方法 将65例T2DM患者(T2DM组)分为T2DM无并发症组(34例)和T2DM合并大血管病变组(31例),另选取30例健康体检者作为对照组.采用ELISA法测定SAA和IL-18水平,并进行相关性分析.结果 T2DM组患者SAA、IL-18水平[(3.09±0.96)mg/L和(98.8±36.4)ng/L]显著高于对照组[(1.06±0.45)mg/L和(58.9±15.6)ng/L],差异均有统计学意义(P<0.05),T2DM合并大血管病变组患者SAA、IL-18水平[(6.34±1.52)mg/L和(141.2±48.3)ne/L]与T2DM无并发症组患者[(2.65±0.39)mg/L,(80.2±20.1)ng/L]比较差异均有统计学意义(P<0.05).另外相关分析显示:SAA与IL-18呈正相关(r=0.615,P<0.05),SAA、IL-18分别与空腹血糖呈正相关(r=0.312、0.428,P<0.05).结论 SAA、IL-18在T2DM及合并大血管病变患者中明显升高,在其发生和发展中具有重要的临床意义,可能是T2DM合并大血管病变的重要危险因素.
目的 探討血清澱粉樣蛋白A(SAA)、白細胞介素(IL)-18與2型糖尿病(T2DM)及其閤併大血管病變的關繫.方法 將65例T2DM患者(T2DM組)分為T2DM無併髮癥組(34例)和T2DM閤併大血管病變組(31例),另選取30例健康體檢者作為對照組.採用ELISA法測定SAA和IL-18水平,併進行相關性分析.結果 T2DM組患者SAA、IL-18水平[(3.09±0.96)mg/L和(98.8±36.4)ng/L]顯著高于對照組[(1.06±0.45)mg/L和(58.9±15.6)ng/L],差異均有統計學意義(P<0.05),T2DM閤併大血管病變組患者SAA、IL-18水平[(6.34±1.52)mg/L和(141.2±48.3)ne/L]與T2DM無併髮癥組患者[(2.65±0.39)mg/L,(80.2±20.1)ng/L]比較差異均有統計學意義(P<0.05).另外相關分析顯示:SAA與IL-18呈正相關(r=0.615,P<0.05),SAA、IL-18分彆與空腹血糖呈正相關(r=0.312、0.428,P<0.05).結論 SAA、IL-18在T2DM及閤併大血管病變患者中明顯升高,在其髮生和髮展中具有重要的臨床意義,可能是T2DM閤併大血管病變的重要危險因素.
목적 탐토혈청정분양단백A(SAA)、백세포개소(IL)-18여2형당뇨병(T2DM)급기합병대혈관병변적관계.방법 장65례T2DM환자(T2DM조)분위T2DM무병발증조(34례)화T2DM합병대혈관병변조(31례),령선취30례건강체검자작위대조조.채용ELISA법측정SAA화IL-18수평,병진행상관성분석.결과 T2DM조환자SAA、IL-18수평[(3.09±0.96)mg/L화(98.8±36.4)ng/L]현저고우대조조[(1.06±0.45)mg/L화(58.9±15.6)ng/L],차이균유통계학의의(P<0.05),T2DM합병대혈관병변조환자SAA、IL-18수평[(6.34±1.52)mg/L화(141.2±48.3)ne/L]여T2DM무병발증조환자[(2.65±0.39)mg/L,(80.2±20.1)ng/L]비교차이균유통계학의의(P<0.05).령외상관분석현시:SAA여IL-18정정상관(r=0.615,P<0.05),SAA、IL-18분별여공복혈당정정상관(r=0.312、0.428,P<0.05).결론 SAA、IL-18재T2DM급합병대혈관병변환자중명현승고,재기발생화발전중구유중요적림상의의,가능시T2DM합병대혈관병변적중요위험인소.
Objective To investigate the serum amyloid A (SAA) and interleukin-18(IL-18)concentration in the pathogenesis of type 2 diabetes mellitus (T2DM) and its macrovascular complications, and study the relation between them. Methods ELISA was used to assay serum SAA and IL-18 levels in 65 T2DM patients (including 31 cases with macrovascular complications) and 30 healthy controls. Results Serum SAA and IL-18 levels [(3.09±0.96)mg/L, (98.8±36.4)ng/L]were significantly elevated in patients with T2DM as compared with those in control subjects [(1.06±0.45)mg/L, (58.9±15.6)ng/L](P<0.05). There was significant difference of SAA and IL-18 levels between T2DM patients with [(6.34±1.52) mg/L,(141.2±48.3)ng/L]and without macrovascukar complications [(2.65±0.39)mg/L, (80.2±20.1)ng/L](P < 0.05).Univariate linear regression analysis showed significant positive correlations between serum IL-18 with SAA (r =0.615, P<0.05), SAA, IL-18 and fasting blood glucose (FBG) had mutual positive correlations (r=0.312, 0.428, P< 0.05, respectively). Conclusions In patients with T2DM, serum SAA and IL-18 concentration is greater than in non-diabetic subjects. SAA and IL-18 play important roles in the initiation and development of T2DM. The study suggests that SAA and IL-18 might be an important independent risk factor.
