CAJ | 학술논문

Toll样受体3(TLR3)是参与天然免疫的一类重要分子,是病毒双链RNA的模式识别受体.TLR3表达于免疫细胞和某些非免疫细胞如皮肤角质化细胞、纤维母细胞和肺上皮细胞等,近年来发现人肿瘤组织中也有TLR3表达.TLR3配体双链RNA能直接激活自然杀伤细胞,增强抗原特异性CD8+ T细胞应答,促进树突状细胞的抗原呈递激活.双链RNA也能通过激活多条信号转导途径,直接诱导肿瘤细胞凋亡.TLR3激动剂作为免疫佐剂已应用到某些肿瘤的辅助性免疫治疗.TLR3在肿瘤免疫中的作用及其相关分子机制值得进一步深入研究.
Toll양수체3(TLR3)시삼여천연면역적일류중요분자,시병독쌍련RNA적모식식별수체.TLR3표체우면역세포화모사비면역세포여피부각질화세포、섬유모세포화폐상피세포등,근년래발현인종류조직중야유TLR3표체.TLR3배체쌍련RNA능직접격활자연살상세포,증강항원특이성CD8+ T세포응답,촉진수돌상세포적항원정체격활.쌍련RNA야능통과격활다조신호전도도경,직접유도종류세포조망.TLR3격동제작위면역좌제이응용도모사종류적보조성면역치료.TLR3재종류면역중적작용급기상관분자궤제치득진일보심입연구.
Toll-like receptor 3(TLR3)is the critical component of the innate immune system that serves to identify viral double stranded RNA (dsRNA).TLR3 is expressed in immune cells and some nonimmune cells,such as keratinocytes,fibroblast and pulmonary epithelial cells.Recently,it has been reported that TLR3 is expressed in some tumor cell lines.TLR3 ligand dsRNA can directly activate natural killer cells,enhance antigen-specific CD8+ T cell responses,and promote antigen presentation by dendritic cells.They can also induce apoptosis of tumor cells via activating multiple signal transduction pathways.TLR3 agonists,as immunoadjuvant,have been applied for adjuvant immunotherapy of some tumors.Further studied should be conducted on the effect of TLR3 in tumor immunity and its relative molecular mechanism.