CAJ | 학술논문

目的观察手汗症伴腋窝多汗患者(腋窝多汗组)、手汗症无腋窝多汗患者(单纯型手汗症组)及非手汗症患者(对照组)的腋窝汗腺数目及Na+K+Cl-联合转运子1(NKCC1)的表达,探讨其与手汗症发病的关系.方法 27例腋窝多汗组,11例单纯型手汗症组,8例对照组,取各组患者腋窝皮肤作常规苏木素.伊红(HE)染色,计数汗腺数目,并检测NKCC1在3组患者腋窝皮肤汗腺中的表达和分布.结果 3组汗腺计数差异均无统计学意义(HC=2.528,P>0.05).腋窝多汗组与单纯型手汗症组、对照组NKCC1的吸光度差异有统计学意义(F=5.158,P<0.05;F=5.158,P<0.01),单纯型手汗症组与对照组差异无统计学意义(F=5.158,P>0.05).结论伴有腋窝多汗的手汗症患者腋汗增多与NKCC1蛋白表达增强有关,而与腋窝汗腺数目无关.
목적 관찰수한증반액와다한환자(액와다한조)、수한증무액와다한환자(단순형수한증조)급비수한증환자(대조조)적액와한선수목급Na+K+Cl-연합전운자1(NKCC1)적표체,탐토기여수한증발병적관계.방법 27례액와다한조,11례단순형수한증조,8례대조조,취각조환자액와피부작상규소목소.이홍(HE)염색,계수한선수목,병검측NKCC1재3조환자액와피부한선중적표체화분포.결과 3조한선계수차이균무통계학의의(HC=2.528,P>0.05).액와다한조여단순형수한증조、대조조NKCC1적흡광도차이유통계학의의(F=5.158,P<0.05;F=5.158,P<0.01),단순형수한증조여대조조차이무통계학의의(F=5.158,P>0.05).결론 반유액와다한적수한증환자액한증다여NKCC1단백표체증강유관,이여액와한선수목무관.
Objective To examine the number of axillary sweat glands and the expression of Na+ K+ Cl+ cotransporter isoform1(NKCC1) in axillary sweat glands of palmar hyperhidrosis patients with axillary hyperhidrosis, palmar hyperhidrosis patients and non-hyperhidrosis patients, to investigate its relationship with the pathogenesis of palmar hyperhidrosis. Methods Axillary glands were gained in 27 cases of palmar hyperhidrosis with axillary hyperhidrosis, 11 cases of palmar hyperhidrosis and 8 cases of non-hyperhidrosis as control group. The number of axillary sweat glands was calculated by using HE staining and the expression of NKCC1 was detected respectively. Results The number of axillary sweat glands in three groups had no significant difference in statistics (HC=2.528 ,P>0.05). There was significant difference in the expression of NKCC1 between palamar hyperhidrosis patients with axillary hyperhidrosis and palmar hyperhidrosis patients (F=5.158,P<0.05), and there was significant difference between palamar hyper-hidrosis patients with axillary hyperhidrosis and control group (F=5.158,P<0.01 ) , but there was no significant difference between palmar hyperhidrosis patients and control group(F=5.158, P>0.05). Conclusion The increase of NKCC1 expression has the relationship with axillary hyperhidrosis of palmar hyperhidrosis patients with axillary hyperhidrosis, but has no relationship with the number of axillary sweat glands.