中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2010年
4期
236-240
,共5页
胰腺癌%无病生存%回顾性研究
胰腺癌%無病生存%迴顧性研究
이선암%무병생존%회고성연구
Pancreatic neoplasms%Disease-free survival%Retrospective studies
目的 观察胰腺癌患者临床特征、血常规、生化指标对预后的影响.方法 电话随访病理诊断明确为胰腺癌患者的生存期,收集临床特征、血常规、生化指标,分析资料齐全的204例患者各因素对预后的影响.结果 204例胰腺癌患者1、2、3年生存率分别为32.8%、13.7%、2.9%,中位生存期为6.4个月.单因素分析显示未手术治疗患者较行根治性切除术或姑息手术患者的生存期短(P<0.01);肿瘤标志物高、血红蛋白低、白细胞高、血清白蛋白低、血清肌酐水平高的患者生存期短(P<0.01);丙氨酸转氨酶及天冬氨酸转氨酶高的患者较正常患者生存期长(P<0.05).COX回归分析显示分期晚的患者生存时间短(P<0.01);血清白蛋白低、血清肌酐高患者生存时间短(P<0.05).结论 手术、临床分期、肿瘤标志物水平、血红蛋白、白细胞、血清白蛋白、血清肌酐均为影响胰腺癌患者预后的独立危险因素.
目的 觀察胰腺癌患者臨床特徵、血常規、生化指標對預後的影響.方法 電話隨訪病理診斷明確為胰腺癌患者的生存期,收集臨床特徵、血常規、生化指標,分析資料齊全的204例患者各因素對預後的影響.結果 204例胰腺癌患者1、2、3年生存率分彆為32.8%、13.7%、2.9%,中位生存期為6.4箇月.單因素分析顯示未手術治療患者較行根治性切除術或姑息手術患者的生存期短(P<0.01);腫瘤標誌物高、血紅蛋白低、白細胞高、血清白蛋白低、血清肌酐水平高的患者生存期短(P<0.01);丙氨痠轉氨酶及天鼕氨痠轉氨酶高的患者較正常患者生存期長(P<0.05).COX迴歸分析顯示分期晚的患者生存時間短(P<0.01);血清白蛋白低、血清肌酐高患者生存時間短(P<0.05).結論 手術、臨床分期、腫瘤標誌物水平、血紅蛋白、白細胞、血清白蛋白、血清肌酐均為影響胰腺癌患者預後的獨立危險因素.
목적 관찰이선암환자림상특정、혈상규、생화지표대예후적영향.방법 전화수방병리진단명학위이선암환자적생존기,수집림상특정、혈상규、생화지표,분석자료제전적204례환자각인소대예후적영향.결과 204례이선암환자1、2、3년생존솔분별위32.8%、13.7%、2.9%,중위생존기위6.4개월.단인소분석현시미수술치료환자교행근치성절제술혹고식수술환자적생존기단(P<0.01);종류표지물고、혈홍단백저、백세포고、혈청백단백저、혈청기항수평고적환자생존기단(P<0.01);병안산전안매급천동안산전안매고적환자교정상환자생존기장(P<0.05).COX회귀분석현시분기만적환자생존시간단(P<0.01);혈청백단백저、혈청기항고환자생존시간단(P<0.05).결론 수술、림상분기、종류표지물수평、혈홍단백、백세포、혈청백단백、혈청기항균위영향이선암환자예후적독립위험인소.
Objective To investigate the impacts of clinical features, blood and biochemical parameters on survival of patients with pancreatic cancer. Methods Two hundred and four patients with pathologically performed pancreatic cancer were retrospectively analyzed. All patients were followed-up by means of phone. Results The survival rate of 204 patients with pancreatic cancer was 32.8% at 1-year, 13.7% at 3-year and 2.9% at 5-year, with medium survival time of 6.4 months. Univariate examination showed that the long survival time was found in patients with radical or palliate operation in comparison with those without (P<0.01). The factors that impacted on the survival times were high tumor marker, .high serum creatinine, high white blood cells, low hemoglobin and low albumin (P<0.01). Whereas the patients with high levels of ALT and AST had long survival time (P(0.05). COX regression analysis revealed that those with advanced stage, low albumin and high creatinine had short survival time(P<0.05). Conclusions Surgery, tumor stage, tumor marker, hemoglobin, white blood cell, albumin and creatinine are independent prognostic factors.
