生命科学
生命科學
생명과학
CHINESE BULLETIN OF LIFE SCIENCES
2005年
5期
439-444
,共6页
IGF-2r%M6P受体%IGF%溶酶体酶%基因印迹%胚胎发育
IGF-2r%M6P受體%IGF%溶酶體酶%基因印跡%胚胎髮育
IGF-2r%M6P수체%IGF%용매체매%기인인적%배태발육
胰岛素样生长因子-2受体(insulin-like growth factor-2 receptor,IGF-2r)和非阳离子依赖型甘露糖-6-磷酸受体(cation-independent mannose-6-phosphate receptor,CI-MPR)为同一分子,属多结构域跨膜糖蛋白.IGF-2r与阳离子依赖型M6P受体(cation-dependent mannose-6-phosphotase receptor,CD-MPR)共同介导溶酶体酶的分选和转运过程,对溶酶体的形成起重要作用.IGF-2/M6P受体除能与溶酶体酶、TGF-β前体等M6P配体结合外,还能与非糖基化的IGF-2、视黄酸等作用,调节蛋白质的转运和跨膜信号传导等活动.IGF-2r为父源性印迹(paternal imprinted)基因,基因的印迹、表达受基因印迹控制区(imprinting control region,ICR)的甲基化差异修饰所调控.IGF-2r基因表达缺失出现胎儿肥大、心脏和胎盘发育不全、围产期死亡等异常现象,证明IGF-2r在胚胎发育过程中起重要作用.
胰島素樣生長因子-2受體(insulin-like growth factor-2 receptor,IGF-2r)和非暘離子依賴型甘露糖-6-燐痠受體(cation-independent mannose-6-phosphate receptor,CI-MPR)為同一分子,屬多結構域跨膜糖蛋白.IGF-2r與暘離子依賴型M6P受體(cation-dependent mannose-6-phosphotase receptor,CD-MPR)共同介導溶酶體酶的分選和轉運過程,對溶酶體的形成起重要作用.IGF-2/M6P受體除能與溶酶體酶、TGF-β前體等M6P配體結閤外,還能與非糖基化的IGF-2、視黃痠等作用,調節蛋白質的轉運和跨膜信號傳導等活動.IGF-2r為父源性印跡(paternal imprinted)基因,基因的印跡、錶達受基因印跡控製區(imprinting control region,ICR)的甲基化差異脩飾所調控.IGF-2r基因錶達缺失齣現胎兒肥大、心髒和胎盤髮育不全、圍產期死亡等異常現象,證明IGF-2r在胚胎髮育過程中起重要作用.
이도소양생장인자-2수체(insulin-like growth factor-2 receptor,IGF-2r)화비양리자의뢰형감로당-6-린산수체(cation-independent mannose-6-phosphate receptor,CI-MPR)위동일분자,속다결구역과막당단백.IGF-2r여양리자의뢰형M6P수체(cation-dependent mannose-6-phosphotase receptor,CD-MPR)공동개도용매체매적분선화전운과정,대용매체적형성기중요작용.IGF-2/M6P수체제능여용매체매、TGF-β전체등M6P배체결합외,환능여비당기화적IGF-2、시황산등작용,조절단백질적전운화과막신호전도등활동.IGF-2r위부원성인적(paternal imprinted)기인,기인적인적、표체수기인인적공제구(imprinting control region,ICR)적갑기화차이수식소조공.IGF-2r기인표체결실출현태인비대、심장화태반발육불전、위산기사망등이상현상,증명IGF-2r재배태발육과정중기중요작용.
