国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2010年
6期
496-497
,共2页
张建国%石炳娟%周建民%杨光
張建國%石炳娟%週建民%楊光
장건국%석병연%주건민%양광
压力性溃疡%中药组方%药理作用%抗炎作用
壓力性潰瘍%中藥組方%藥理作用%抗炎作用
압력성궤양%중약조방%약리작용%항염작용
Pressure ulcer%Medicines party%pharmacological effects%Inflammatory effects
目的 探讨压力性溃疡中药组方的抗炎镇痛作用机理.方法 实验动物应用随机数字表进行随机分组,设中药组方高剂量组、低剂量组,以吲哚美辛组、生理盐水组为对照,通过抑制大鼠角叉菜胶性足跖肿胀实验、醋酸致小鼠腹腔毛细血管通透性实验、醋酸致小鼠扭体反应实验,观察检测受试动物的各项指标.结果 大鼠趾部皮下注射角叉菜胶致炎后,中药组方高剂量组1～6 h足跖肿胀明显低于生理盐水组(P＜0.05),2～6 h抗炎作用与吲哚美辛组无统计学意义(P＞0.05);中药组方高剂量组和低剂量组小鼠腹腔染料渗出减少,与生理盐水组比较,差异有统计学意义(P＜0.05),中药组方高剂量组与吲哚美辛组比较作用强度相当(P＞0.05);中药组方高剂量组和低剂量组小鼠扭体反应次数与生理盐水组比较显著减少(P＜0.05).结论 中药组方高低剂量均有抗炎镇痛作用,作用呈量效正相关.
目的 探討壓力性潰瘍中藥組方的抗炎鎮痛作用機理.方法 實驗動物應用隨機數字錶進行隨機分組,設中藥組方高劑量組、低劑量組,以吲哚美辛組、生理鹽水組為對照,通過抑製大鼠角扠菜膠性足蹠腫脹實驗、醋痠緻小鼠腹腔毛細血管通透性實驗、醋痠緻小鼠扭體反應實驗,觀察檢測受試動物的各項指標.結果 大鼠趾部皮下註射角扠菜膠緻炎後,中藥組方高劑量組1～6 h足蹠腫脹明顯低于生理鹽水組(P＜0.05),2～6 h抗炎作用與吲哚美辛組無統計學意義(P＞0.05);中藥組方高劑量組和低劑量組小鼠腹腔染料滲齣減少,與生理鹽水組比較,差異有統計學意義(P＜0.05),中藥組方高劑量組與吲哚美辛組比較作用彊度相噹(P＞0.05);中藥組方高劑量組和低劑量組小鼠扭體反應次數與生理鹽水組比較顯著減少(P＜0.05).結論 中藥組方高低劑量均有抗炎鎮痛作用,作用呈量效正相關.
목적 탐토압력성궤양중약조방적항염진통작용궤리.방법 실험동물응용수궤수자표진행수궤분조,설중약조방고제량조、저제량조,이신타미신조、생리염수조위대조,통과억제대서각차채효성족척종창실험、작산치소서복강모세혈관통투성실험、작산치소서뉴체반응실험,관찰검측수시동물적각항지표.결과 대서지부피하주사각차채효치염후,중약조방고제량조1～6 h족척종창명현저우생리염수조(P＜0.05),2～6 h항염작용여신타미신조무통계학의의(P＞0.05);중약조방고제량조화저제량조소서복강염료삼출감소,여생리염수조비교,차이유통계학의의(P＜0.05),중약조방고제량조여신타미신조비교작용강도상당(P＞0.05);중약조방고제량조화저제량조소서뉴체반응차수여생리염수조비교현저감소(P＜0.05).결론 중약조방고저제량균유항염진통작용,작용정량효정상관.
Objective To discuss the anti-inflammatory and analgesic effects of traditional Chinese formula (TCF)on pressure ulcer. Methods The experimental animals were randomly divided into TCF high-dose group, TCF low dose group, indomethacin group, and saline group. through the inhibition of rat carrageenin paw edema test, acetic acid-induced small murine peritoneal capillary permeability experiments, acetic acid-induced writhing response in mice experiments,subjects observe the animals indicators. Results Rat plantar subcutaneous injection of carrageenan-induced inflammation,the compound traditional Chinese medicine set of square high-dose group 1 ～6 h paw edema was significantly lower than saline control group (P＜0.05), 2～6 h anti-inflammation and indomethacin Xin was no significant difference (P＞0.05);compound Chinese medicine set of square high-dose group and low dose group mice dye leakage reduction compared with the saline group was statistically significant (P＜0.05), high-dose group and the indomethacin group effect was no significant difference in strength (P＞0.05); compound Chinese medicine set of square high-dose group and low dose group the number of writhing response in mice compared with saline significantly reduce(P＜0.05). Conclusion Prescription medicine compound high-dose, low dose has anti-inflammatory effects, analgesic effects, Pharmacological effect was dose-proportional relationship.
