中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2008年
4期
248-251
,共4页
杜培宜%黄北春%杜松%赵秀芹%李三纪%彭静
杜培宜%黃北春%杜鬆%趙秀芹%李三紀%彭靜
두배의%황북춘%두송%조수근%리삼기%팽정
甲状腺功能亢进症%甲状腺功能减退症%氧化性应激%载脂蛋白%脂肪酸类,非酯化
甲狀腺功能亢進癥%甲狀腺功能減退癥%氧化性應激%載脂蛋白%脂肪痠類,非酯化
갑상선공능항진증%갑상선공능감퇴증%양화성응격%재지단백%지방산류,비지화
Hyperthyroidism%Hypothyroidism%Oxidative stress%Apolipoproteins%Fatty acids，nonesterified
目的 探讨老年人不同甲状腺功能状态下脂代谢特征与氧化应激的关系.方法 初诊老年甲状腺疾病患者86例[甲状腺功能亢进(甲亢)47例,甲状腺功能减退(甲减)39例]、非老年甲状腺疾病患者83例(甲亢43例,甲减40例)和老年健康对照组20例.检测空腹血浆丙二醛(MDA)和超氧化物歧化酶(SOD),氧化型低密度脂蛋白(OX-LDL)水平,同时测定血脂指标及甲状腺功能,计算SOD/MDA比值.结果 老年甲亢组血脂各组分均高于非老年甲亢组、低于老年对照组(P＜0.05或P＜0.01);老年甲亢组与非老年甲亢组、老年对照组比较,丙二醛[分别为(10.23±6.29)、(7.37±4.58)μmol/L和(3.66±2.53)μmol/L]、游离脂肪酸(FFA)[分别为(0.86±0.58)、(0.61±0.46)mmol/L和(0.45士0.12)mmol/L]和SOD显著升高(P＜0.01或P＜0.05).老年甲减组与非老年甲减组和老年对照组比较,MDA[(9.03±5.98)、(6.59±3.18)μmol/L和(3.66±2.53)μmol/L]、OX-LDL[(387.36±71.04)、(355.22±45.01)μg/L和(324.53±56.19)μg/L]及部分血脂组分均显著增高(P＜0.05或P＜O.01).老年甲亢组、甲减组SOD/MDA比值均低于老年对照组和非老年组(均为P＜0.01).多元回归分析,甲亢组游离甲状腺素(FT4)和FFA是影响MDA的因素,甲减组非HDL-C和LDL-C与MDA独立相关.结论 初诊老年甲亢和甲减患者氧化应激增强,氧化损伤程度与脂代谢紊乱有关.
目的 探討老年人不同甲狀腺功能狀態下脂代謝特徵與氧化應激的關繫.方法 初診老年甲狀腺疾病患者86例[甲狀腺功能亢進(甲亢)47例,甲狀腺功能減退(甲減)39例]、非老年甲狀腺疾病患者83例(甲亢43例,甲減40例)和老年健康對照組20例.檢測空腹血漿丙二醛(MDA)和超氧化物歧化酶(SOD),氧化型低密度脂蛋白(OX-LDL)水平,同時測定血脂指標及甲狀腺功能,計算SOD/MDA比值.結果 老年甲亢組血脂各組分均高于非老年甲亢組、低于老年對照組(P＜0.05或P＜0.01);老年甲亢組與非老年甲亢組、老年對照組比較,丙二醛[分彆為(10.23±6.29)、(7.37±4.58)μmol/L和(3.66±2.53)μmol/L]、遊離脂肪痠(FFA)[分彆為(0.86±0.58)、(0.61±0.46)mmol/L和(0.45士0.12)mmol/L]和SOD顯著升高(P＜0.01或P＜0.05).老年甲減組與非老年甲減組和老年對照組比較,MDA[(9.03±5.98)、(6.59±3.18)μmol/L和(3.66±2.53)μmol/L]、OX-LDL[(387.36±71.04)、(355.22±45.01)μg/L和(324.53±56.19)μg/L]及部分血脂組分均顯著增高(P＜0.05或P＜O.01).老年甲亢組、甲減組SOD/MDA比值均低于老年對照組和非老年組(均為P＜0.01).多元迴歸分析,甲亢組遊離甲狀腺素(FT4)和FFA是影響MDA的因素,甲減組非HDL-C和LDL-C與MDA獨立相關.結論 初診老年甲亢和甲減患者氧化應激增彊,氧化損傷程度與脂代謝紊亂有關.
목적 탐토노년인불동갑상선공능상태하지대사특정여양화응격적관계.방법 초진노년갑상선질병환자86례[갑상선공능항진(갑항)47례,갑상선공능감퇴(갑감)39례]、비노년갑상선질병환자83례(갑항43례,갑감40례)화노년건강대조조20례.검측공복혈장병이철(MDA)화초양화물기화매(SOD),양화형저밀도지단백(OX-LDL)수평,동시측정혈지지표급갑상선공능,계산SOD/MDA비치.결과 노년갑항조혈지각조분균고우비노년갑항조、저우노년대조조(P＜0.05혹P＜0.01);노년갑항조여비노년갑항조、노년대조조비교,병이철[분별위(10.23±6.29)、(7.37±4.58)μmol/L화(3.66±2.53)μmol/L]、유리지방산(FFA)[분별위(0.86±0.58)、(0.61±0.46)mmol/L화(0.45사0.12)mmol/L]화SOD현저승고(P＜0.01혹P＜0.05).노년갑감조여비노년갑감조화노년대조조비교,MDA[(9.03±5.98)、(6.59±3.18)μmol/L화(3.66±2.53)μmol/L]、OX-LDL[(387.36±71.04)、(355.22±45.01)μg/L화(324.53±56.19)μg/L]급부분혈지조분균현저증고(P＜0.05혹P＜O.01).노년갑항조、갑감조SOD/MDA비치균저우노년대조조화비노년조(균위P＜0.01).다원회귀분석,갑항조유리갑상선소(FT4)화FFA시영향MDA적인소,갑감조비HDL-C화LDL-C여MDA독립상관.결론 초진노년갑항화갑감환자양화응격증강,양화손상정도여지대사문란유관.
Objective To investigate the relationship between oxidative stress and lipid metabolism characteristics in elderly patients under different status of thyroid function. Methods Eighty-six newly-diagnosed elderly patients with thyroid diseases,83 non-elderly patients with thyroid diseases and 20 normal subjects as control were selected.and 47 hyperthyroidism and 39hypothyroidism in elderly,43 hyperthyroidism and 40 hypothyroidism in non-elderly were diagnosed according to diagnostic criteria of the thyroid disease.The levels of fasting plasma malondialdehyde(MDA),superoxide(SOD)and oxidized low density lipoprotein(OX-LDL)were measured by thiobarhiturates,colorimetric method and enzyme linked immunosorbent assay(ELISA).Meanwhile,lipid profile and thyroid function were also measured,SOD/MDA ratio was calculated. Results Lipid profiles in the elderly hyperthyroidism group were significantly higher than those in the non-elderly group(P＜O.05 or P＜0.01)but were significantly lower than those of normal control group(P＜0.05 or P＜0.01).The plasma MDA[(10.23±6.29)μmol/L vs.(3.66±2.53)μmol/L vs.(7.37±4.58)μmol/L],free fatty acids(FFA)[(0.86±0.58)mmol/L us.(0.45±0.12)mmol/L vs.(0.61±O.46)mmol/L]and SOD levels were significantly higher in elderly patients with hyperthyroidism than in normal control and non-elderly hyperthyroidism groups(P＜0.05 or P＜O.01).In the patients with hypothyroidism,the plasma MDA[(9.03±5.98)μmol/L vs.(6.59±3.18)μmol/L vs.(3.66±2.53)μmol/L],OX-LDL[(387.36±71.04)μg/L vs.(355.22±45.01)μg/L vs.(324.53±56.19)μg/L],TC,LDL-C,non-HDL-C,LP(a) and Apo-B100 levels were significantly higher in the elderly group than in the non-elderly and normal control groups(P＜0.05 orP＜0.01).The SOD/MDA ratio was significantly lower in the elderly patient groups with hyperthyroidism or hypothyroidism than in normal control and non-elderly groups(all P＜0.01).In a multiple step-wise regression analysis.FT4 and FFA were independent factors related tO MDA in hyperthyroidism group,and non-HDL-C and LDL-C were independent factors related to MDA inhypothyroidism group. Conclusions Serious lipid metabolic disorder exists in newly-diagnosed and untreated elderly patients with hyperthyroidism and hypothyroidism.It is suggested that oxidative stress is obviously strengthened in elderly patients with thyroid function disorder and that the degree of oxidative stress is correlated with lipid metabolic disorder.
