CAJ | 학술논문

目的综述关于微重力引起航天员骨质疏松的研究进展. 资料来源与选择国内外该领域相关文献. 资料引用公开发表的相关文献48篇. 资料综合详细介绍了微重力对骨髓间充质干细胞成骨向分化的影响和微重力对成骨细胞的影响；总结了微重力对骨细胞及破骨细胞影响的最新进展. 结论微重力不但影响骨组织细胞的形态、增殖、凋亡,也影响其分化和功能等方面,导致骨形成减少,骨吸收增加,引起骨丢失.
목적 종술관우미중력인기항천원골질소송적연구진전. 자료래원여선택 국내외해영역상관문헌. 자료인용 공개발표적상관문헌48편. 자료종합 상세개소료미중력대골수간충질간세포성골향분화적영향화미중력대성골세포적영향；총결료미중력대골세포급파골세포영향적최신진전. 결론 미중력불단영향골조직세포적형태、증식、조망,야영향기분화화공능등방면,도치골형성감소,골흡수증가,인기골주실.
Objective To sum up the researches on osteoporosis induced by microgravity Literature resources and selection The related articles published at home and abroad. Literature quotation Forty-eight references were cited. Literature synthesis The effects of microgravity on osteoblast and the differentiation process from bone marrow mesenchymal stem cells(BMSCs) to mature osteoblast were introduced in details.In addition,researches on the effects of microgravity on osteocyte and osteoclast were summarized. Conclusion Microgravity affects the morphology,proliferation,apoplosis,differentiation and functions of bone cells,which results in the decrease of bone formation and increase of bone resorption,and induces bone loss.