中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2009年
11期
754-757
,共4页
邢玉平%张丽芳%王玉芬%孙万里%武桂花%申亚巍%崔丽霞
邢玉平%張麗芳%王玉芬%孫萬裏%武桂花%申亞巍%崔麗霞
형옥평%장려방%왕옥분%손만리%무계화%신아외%최려하
咖啡因%苯甲酸钠%中毒%脑损害%慢性%磁共振成像
咖啡因%苯甲痠鈉%中毒%腦損害%慢性%磁共振成像
가배인%분갑산납%중독%뇌손해%만성%자공진성상
Caffeine%Sodium benzoate%Poisoning%Brain damage,chronic%Magnetic resonance imaging
目的 探讨安钠咖相关脑损害的临床表现及磁共振成像(MRI)特征.方法 对3例安钠咖相关脑损害患者进行临床及MRI观察.结果 3例均为男性,均有明确的烫吸安钠咖史(烫吸时间3~7年),除具有反应迟钝、智力障碍等常见的中毒性脑病特征外,尚有特殊的语言及肌张力障碍;头颅MRI显示双侧对称性大脑半球、内囊后肢、胼胝体、双侧大脑脚、脑桥的广泛脱髓鞘改变.3例经皮质激素、神经营养等治疗,在病后40 d病情均明显好转,仅例1残留轻度情感控制障碍.结论 安钠咖相关脑损害有特殊的语言及肌张力障碍,MRI存在广泛脱髓鞘,了解这些特点可为预防和治疗安钠咖引起的并发症提供帮助.
目的 探討安鈉咖相關腦損害的臨床錶現及磁共振成像(MRI)特徵.方法 對3例安鈉咖相關腦損害患者進行臨床及MRI觀察.結果 3例均為男性,均有明確的燙吸安鈉咖史(燙吸時間3~7年),除具有反應遲鈍、智力障礙等常見的中毒性腦病特徵外,尚有特殊的語言及肌張力障礙;頭顱MRI顯示雙側對稱性大腦半毬、內囊後肢、胼胝體、雙側大腦腳、腦橋的廣汎脫髓鞘改變.3例經皮質激素、神經營養等治療,在病後40 d病情均明顯好轉,僅例1殘留輕度情感控製障礙.結論 安鈉咖相關腦損害有特殊的語言及肌張力障礙,MRI存在廣汎脫髓鞘,瞭解這些特點可為預防和治療安鈉咖引起的併髮癥提供幫助.
목적 탐토안납가상관뇌손해적림상표현급자공진성상(MRI)특정.방법 대3례안납가상관뇌손해환자진행림상급MRI관찰.결과 3례균위남성,균유명학적탕흡안납가사(탕흡시간3~7년),제구유반응지둔、지력장애등상견적중독성뇌병특정외,상유특수적어언급기장력장애;두로MRI현시쌍측대칭성대뇌반구、내낭후지、변지체、쌍측대뇌각、뇌교적엄범탈수초개변.3례경피질격소、신경영양등치료,재병후40 d병정균명현호전,부례1잔류경도정감공제장애.결론 안납가상관뇌손해유특수적어언급기장력장애,MRI존재엄범탈수초,료해저사특점가위예방화치료안납가인기적병발증제공방조.
Objective To study the clinical manifestation and MRI feature of toxic encephalopathy after inhaling caffeine and sodium benzoate. Methods Three patients with toxic encephalopathy induced by inhaling caffeine and sodium benzoate were observed clinically and with MRI. Results The 3 patients were male. They all had definite addiction histories (the time of addiction for 3 years to 7 years ). There were special language and retropulsive dystonia besides the common characteristics of toxic encephalopathy:reaction retardation and disturbance of intelligence. MRI showed the change of generalized demyelination in bilateral symmetrical cerebral hemisphere, posterior limbs of internal capsule, corpus callosum, medial lemniscus, and cerebellum hemisphere dentate nucleus. The clinical symptoms of 3 patients were significantly improved 40 days after the adrenocortical steroid and neurotrophic treatment. The mild mood disorder remained in case 1. Conclusion Clinical manifestation and MRI of toxic encephalopathy after inhaling caffeine and sodium benzoate are known, so we could diagnose the patients of the disease in time.