CAJ | 학술논문

以306例早期糖尿病患者为研究对象,采用生存分析的方法探讨血尿酸对早期糖尿病肾病患者预后的影响.结果显示,随访结束时288例临床资料完整,高尿酸组64例,非高尿酸组224例,高尿酸组显性白蛋白尿和肾小球滤过率下降终点事件发生率显著高于非血尿酸组,分别为47.36%与30.29%和66.14%与37.72%(P<0.05),提示高尿酸血症是糖尿病肾病进展的危险因素.
이306례조기당뇨병환자위연구대상,채용생존분석적방법 탐토혈뇨산대조기당뇨병신병환자예후적영향.결과 현시,수방결속시288례림상자료완정,고뇨산조64례,비고뇨산조224례,고뇨산조현성백단백뇨화신소구려과솔하강종점사건발생솔현저고우비혈뇨산조,분별위47.36%여30.29%화66.14%여37.72%(P<0.05),제시고뇨산혈증시당뇨병신병진전적위험인소.
Total 306 patients with early stage diabetes were enrolled in the study, after follow-up for 67 ± 8 months, the data of 288 cases were analyzed with survival analysis method. At the end of study 64 out 288 patients had high serum uric acid and the remaining 224 had normal uric acid levels. The prevalence of dominant proteinuria and reduced GFR were significantly higher in patients with high serum uric acid than those with normal serum uric acid (47. 36% vs 30. 29% and 66. 14% vs 37.72%, respectively, both P <0. 05). The results suggest that high level of serum uric acid is a risk factor for the progress of diabetic nephropathy.