CAJ | 학술논문

目的观察研究多囊卵巢综合征(PCOS)不育患者不同促排卵时机的临床效果.方法 163例PCOS不育患者,根据来诊时不同的月经周期及阴道B超检查情况分为三组:一组为月经周期1～5 d的51例患者,周期第5天开始促排卵治疗;二组为月经周期5 d后,卵泡直径≤9 mm且子宫内膜厚度＜8 mm 62例的患者,来诊当日开始促排卵治疗,三组为月经周期5 d后,卵泡直径＞9 mm且子宫内膜厚度＜8 mm的50例患者,来诊当日开始促排卵治疗.分别观察三组患者的促卵泡成功率、发育卵泡个数、绒毛膜促性腺激素(HCG)注射日子宫内膜厚度、促排卵药物用量、卵巢过度刺激综合征(OHSS)发生率、未破裂卵泡黄素化(LUFS)形成率、周期临床妊娠率、多胎妊娠率、流产率.结果三个组(163个周期)促排卵治疗结果显示:一、二组各项结果经统计学处理差异均无统计学意义(P＞0 05);第三组与一、二组比较,促卵泡成功率、发育卵泡个数、HMG用量、OHSS发生率比较差异有统计学意义(P＜0 05).结论三组均达到了理想的治疗效果,且第三组优于一、二组;PCOS不育患者无月经来潮给予促排卵治疗是一种安全、有效的方法,从而为PCOS不育患者提供了更多的受孕机会.
목적 관찰연구다낭란소종합정(PCOS)불육환자불동촉배란시궤적림상효과.방법 163례PCOS불육환자,근거래진시불동적월경주기급음도B초검사정황분위삼조:일조위월경주기1～5 d적51례환자,주기제5천개시촉배란치료;이조위월경주기5 d후,란포직경≤9 mm차자궁내막후도＜8 mm 62례적환자,래진당일개시촉배란치료,삼조위월경주기5 d후,란포직경＞9 mm차자궁내막후도＜8 mm적50례환자,래진당일개시촉배란치료.분별관찰삼조환자적촉란포성공솔、발육란포개수、융모막촉성선격소(HCG)주사일자궁내막후도、촉배란약물용량、란소과도자격종합정(OHSS)발생솔、미파렬란포황소화(LUFS)형성솔、주기림상임신솔、다태임신솔、유산솔.결과 삼개조(163개주기)촉배란치료결과현시:일、이조각항결과경통계학처리차이균무통계학의의(P＞0 05);제삼조여일、이조비교,촉란포성공솔、발육란포개수、HMG용량、OHSS발생솔비교차이유통계학의의(P＜0 05).결론 삼조균체도료이상적치료효과,차제삼조우우일、이조;PCOS불육환자무월경래조급여촉배란치료시일충안전、유효적방법,종이위PCOS불육환자제공료경다적수잉궤회.
Objective To study the clinical effects of different ovulation induction time on polycystic ovary syndrome (PCOS) infertile patients. Methods One hundred and sixty-three cases of infertile patients with PCOS, according to diagnosis with different from that of the menstrual cycle and vaginal ultrasound examination of US were divided into three groups:The first group of the menstrual cycle, 1-5 days 51 cases, accept ovulation treatment in cycle 5 days; The second groups (62 patients) 5 days after the menstrual cycle, follicle diameter ≤ 9 mm and endometrium thickness <8 mm, accept ovulation treatment at the attending day; The third groups (50 patients),five days after the menstrual cycle, follicle diameter >9 mm and endometrium thickness <8 mm, accept ovulation treatment at the attending day; Three groups were observed in patients with follicle-stimulating success rate, the number of developing follicles, chorionic gonadotrophin (HCG) injection on endometrial thickness, ovulation induction drug dosage, ovarian hyperstimulation syndrome (OHSS) incidence of luteinized unruptured follicle (LUFS) formation rate, the cycle clinical pregnancy rate, multiple birth pregnancy rate, miscarriage rate. Results Three groups (163 cycles) showed that ovulation induction: The findings by the first and the second groups had no statistically significant difference(P>0.05); The third group compared with the first group and the second group: follicle-stimulating success rate, the number of developing follicles, HMG dosage, OHSS incidence of statistically significant differences(P<0.05). Conclusions Three groups have reached an ideal therapeutic effect, and the third group is better than the first or the second groups; PCOS infertile patients with non-menstrual cramps for ovulation induction treatment is a safe and effective way, so as to provide patients with PCOS infertility more chances of conceiving.