CAJ | 학술논문

目的观察生长抑素类似物奥曲肽(OCT)对消化系统肿瘤的疗效及对血清胰岛素样生长因子1(IGF-1)的影响.方法将33例不同类型的晚期消化系统肿瘤患者随机分为OCT治疗组(15例)和支持对照组(18例),分别接受OCT(400μg/d)和支持治疗.在治疗前后不同时间点对其进行疗效评定及观察其对IGF-1的影响.结果治疗组患者治疗过程中有4例病情保持稳定,对照组18例全部恶化;治疗组患者中位生存时间6.9个月,较对照组患者的2-3个月明显延长(P＜0.05),生活质量也较对照组明显改善,治疗组治疗后IGF-1水平明显下降(P＜0.05),对照组治疗前后无差异.结论 OCT可明显延长消化系统肿瘤患者的生存时间,改善生活质量,其作用机制可能是通过抑制促肿瘤生长因子IGF-1起作用.
목적 관찰생장억소유사물오곡태(OCT)대소화계통종류적료효급대혈청이도소양생장인자1(IGF-1)적영향.방법 장33례불동류형적만기소화계통종류환자수궤분위OCT치료조(15례)화지지대조조(18례),분별접수OCT(400μg/d)화지지치료.재치료전후불동시간점대기진행료효평정급관찰기대IGF-1적영향.결과 치료조환자치료과정중유4례병정보지은정,대조조18례전부악화;치료조환자중위생존시간6.9개월,교대조조환자적2-3개월명현연장(P＜0.05),생활질량야교대조조명현개선,치료조치료후IGF-1수평명현하강(P＜0.05),대조조치료전후무차이.결론 OCT가명현연장소화계통종류환자적생존시간,개선생활질량,기작용궤제가능시통과억제촉종류생장인자IGF-1기작용.
Objective To observe the curative effects of octreotide on gastrointestinal cancer and its influenee on the serum level of IGF-1.Methods 33 patients diagnosed as advanced gastrointestinal cancer were randomized into 2 groups.15 cases in therapy group received octreotide 400μg/d subcutaneous injection or intravenous injection,other patients were taken as control.Curative effects of octreotide and serum level of IGF-1 on different time were observed before and after therapy.Results 4 cases in therapy group kept stable condition during treatment,all 18 cases in control group deteriorated gradually.The median survival time of octreotide therapy was 6.9 months,longer than that of control group(2.3 months)(P＜0.05),the feeling of well being in therapy group was reported a remarkable improvement.Serum level of IGF-1 decreased obviously after octreotide injection(P＜0.05),but no significant difference in control group.Conclusion Octreotide can prolong the survival duration and improve living quality of patients with advanced gastrointestinal tumors.The mechanism of antitumor is probably through suppression of IGF-1.