有机化学
有機化學
유궤화학
CHINESE JOURNAL OF ORGANIC CHEMISTRY
2010年
1期
120-123
,共4页
L-薄荷醇%薄荷基溴%新薄荷基溴%高立体选择性转变
L-薄荷醇%薄荷基溴%新薄荷基溴%高立體選擇性轉變
L-박하순%박하기추%신박하기추%고입체선택성전변
L-menthol%menthyl bromide%neomenthyl bromide%highly stereoselective transformation
薄荷基溴和新薄荷基溴是一类非常有用的不对称合成中间体.以L-薄荷醇为原料,通过与不同的溴化剂反应高立体选择性地得到薄荷基溴和和新薄荷基溴.当L-薄荷醇与盐酸和无水溴化锌反应时高立体选择性地得到薄荷基溴,当L-薄荷醇与三溴化磷反应时高立体选择性地得到新薄荷基溴.
薄荷基溴和新薄荷基溴是一類非常有用的不對稱閤成中間體.以L-薄荷醇為原料,通過與不同的溴化劑反應高立體選擇性地得到薄荷基溴和和新薄荷基溴.噹L-薄荷醇與鹽痠和無水溴化鋅反應時高立體選擇性地得到薄荷基溴,噹L-薄荷醇與三溴化燐反應時高立體選擇性地得到新薄荷基溴.
박하기추화신박하기추시일류비상유용적불대칭합성중간체.이L-박하순위원료,통과여불동적추화제반응고입체선택성지득도박하기추화화신박하기추.당L-박하순여염산화무수추화자반응시고입체선택성지득도박하기추,당L-박하순여삼추화린반응시고입체선택성지득도신박하기추.
Menthyl bromide and neomenthyl bromide were synthesized from L-menthol via highly stereoselective bromination reactions.When a mixture of concentrated hydrobromic acid and anhydrous zinc bromide was used as the brominating agent,menthyl bromide was stereoselectively formed.Neomenthyl bromide was highly stereoselectively obtained in the circumstance of using phosphorus tribromide as a brominating agent.
