化学世界
化學世界
화학세계
CHEMICAL WORLD
2010年
4期
240-242
,共3页
N-(2-羟基乙基)乙酰胺%2-甲基-2-噁唑啉%脱水
N-(2-羥基乙基)乙酰胺%2-甲基-2-噁唑啉%脫水
N-(2-간기을기)을선알%2-갑기-2-오서람%탈수
N-(2-hydroxyethyl)-acetamide%2-methly-2-0xazoline%dehydration
以N-(2-羟基乙基)乙酰胺为原料,在二水乙酸锌的催化作用下,脱水缩合生成2-甲基-2-噁唑啉,考察了温度、催化剂用量、压力、时间对反应的影响.最佳工艺条件为:m(催化剂):m(N-(2-羟基乙基乙酰胺))=0.15:1,反应温度为185℃,压力为0.01 MPa,反应时间为2 h,收率可达到95%.并考察了催化剂的重复使用情况.产物经质谱进行了结构表征.
以N-(2-羥基乙基)乙酰胺為原料,在二水乙痠鋅的催化作用下,脫水縮閤生成2-甲基-2-噁唑啉,攷察瞭溫度、催化劑用量、壓力、時間對反應的影響.最佳工藝條件為:m(催化劑):m(N-(2-羥基乙基乙酰胺))=0.15:1,反應溫度為185℃,壓力為0.01 MPa,反應時間為2 h,收率可達到95%.併攷察瞭催化劑的重複使用情況.產物經質譜進行瞭結構錶徵.
이N-(2-간기을기)을선알위원료,재이수을산자적최화작용하,탈수축합생성2-갑기-2-오서람,고찰료온도、최화제용량、압력、시간대반응적영향.최가공예조건위:m(최화제):m(N-(2-간기을기을선알))=0.15:1,반응온도위185℃,압력위0.01 MPa,반응시간위2 h,수솔가체도95%.병고찰료최화제적중복사용정황.산물경질보진행료결구표정.
2-Methyl-2-oxazoline was prepared from N-(-2-hydroxyethyl)-acetamide using zinc acetate hydrate as catalyst.The effect of catalyst amount,reaction temperature,reaction time and reaction pressure was studied.The optimum reaction conditions were:m(catalyst):m(N-(2-hydroxyethyl)-acetamide)=0.15:1;reaction temperature,185℃;reaction pressure,0.01 MPa;reaction time,about 2 h.The vield of 2-methyl-2-oxazoline can reach 92%.The reuse of catalyst was investigated.The product was identified by MS.
