CAJ | 학술논문

目的:探讨液基薄层细胞学检测(liquid-based thinPrep cytology test,TCT)联合宫颈活检对诊断宫颈鳞状上皮病变的临床价值.方法:应用TCT对30350例受检者进行宫颁细胞学检查,细胞学检查结果为鳞状上皮异常者,进行阴道镜活检及病理检查.结果:TCT检出鳞状上皮异常者1 824例(6.01％),其中无明确意义的不典型鳞状细胞(atypical squamous cells of undetermined significance,ASC-US)1423例,不除外高度鳞状上皮病变的不典型鳞状细胞(atypical squamous cells cannot exclude high grade intraepithelial lesion,ASC-H)214例,低度鳞状上皮内病变(low grade squamous intraepithelial lesion,LSIL) 92例,高度鳞状上皮内病变(high grade squamous intraepithelial lesion,HSIL) 80例,鳞状细胞癌(squamous cell carcinoma,SCC) 15例.与活检病理检测结果相比,1423例ASC-US中,宫颁上皮内瘤样病变-Ⅰ级(grade Ⅰ cervical intraepithelial neoplasia,CIN-Ⅰ)202例、CIN- Ⅱ和CIN- Ⅲ 22例、SCC 1例；214例ASC-H中,CIN-Ⅰ 12例、CIN-Ⅱ和CIN-Ⅲ 101例、SCC5例:LSIL、HSIL及SCC组中与组织病理检测结果的符合率分别为63.04％( 58/92)、81.25％ (65/80)及100％( 15/15),SCC组和HSIL组的组织学符合率高于LSIL组(P＜0.01).结论:TCT与阴道镜活检病理检测结果有较高的符合率,二者联合能提高宫颈癌前病变及癌变的检出率.
목적:탐토액기박층세포학검측(liquid-based thinPrep cytology test,TCT)연합궁경활검대진단궁경린상상피병변적림상개치.방법:응용TCT대30350례수검자진행궁반세포학검사,세포학검사결과위린상상피이상자,진행음도경활검급병리검사.결과:TCT검출린상상피이상자1 824례(6.01％),기중무명학의의적불전형린상세포(atypical squamous cells of undetermined significance,ASC-US)1423례,불제외고도린상상피병변적불전형린상세포(atypical squamous cells cannot exclude high grade intraepithelial lesion,ASC-H)214례,저도린상상피내병변(low grade squamous intraepithelial lesion,LSIL) 92례,고도린상상피내병변(high grade squamous intraepithelial lesion,HSIL) 80례,린상세포암(squamous cell carcinoma,SCC) 15례.여활검병리검측결과상비,1423례ASC-US중,궁반상피내류양병변-Ⅰ급(grade Ⅰ cervical intraepithelial neoplasia,CIN-Ⅰ)202례、CIN- Ⅱ화CIN- Ⅲ 22례、SCC 1례；214례ASC-H중,CIN-Ⅰ 12례、CIN-Ⅱ화CIN-Ⅲ 101례、SCC5례:LSIL、HSIL급SCC조중여조직병리검측결과적부합솔분별위63.04％( 58/92)、81.25％ (65/80)급100％( 15/15),SCC조화HSIL조적조직학부합솔고우LSIL조(P＜0.01).결론:TCT여음도경활검병리검측결과유교고적부합솔,이자연합능제고궁경암전병변급암변적검출솔.