国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
21期
1650-1653
,共4页
氧化应激%NADPH氧化酶%急性肺损伤%急性呼吸窘迫综合征
氧化應激%NADPH氧化酶%急性肺損傷%急性呼吸窘迫綜閤徵
양화응격%NADPH양화매%급성폐손상%급성호흡군박종합정
Oxidative Stress%NADPH oxidase%Acute lung injury%Acute respiratory distresssyndrome
NADPH氧化酶是机体活性氧自由基(ROS)的重要产生来源,至今已发现7个相关的亚型而统称为NOX/DUOX蛋白家族,各亚型结构和功能相似,具有组织分布特异性.ROS具有破坏病原微生物及作为细胞内信号转导第二信使等重要生理功能,与脓毒症诱发的急性肺损伤、机械通气后继发的呼吸机相关性肺损伤等密切相关.对NADPH氧化酶产生ROS的过程进行调控可能是防治急性肺损伤的途径之一.本文根据最新研究进展,对NADPH氧化酶与急性肺损伤的相关性进行综述.
NADPH氧化酶是機體活性氧自由基(ROS)的重要產生來源,至今已髮現7箇相關的亞型而統稱為NOX/DUOX蛋白傢族,各亞型結構和功能相似,具有組織分佈特異性.ROS具有破壞病原微生物及作為細胞內信號轉導第二信使等重要生理功能,與膿毒癥誘髮的急性肺損傷、機械通氣後繼髮的呼吸機相關性肺損傷等密切相關.對NADPH氧化酶產生ROS的過程進行調控可能是防治急性肺損傷的途徑之一.本文根據最新研究進展,對NADPH氧化酶與急性肺損傷的相關性進行綜述.
NADPH양화매시궤체활성양자유기(ROS)적중요산생래원,지금이발현7개상관적아형이통칭위NOX/DUOX단백가족,각아형결구화공능상사,구유조직분포특이성.ROS구유파배병원미생물급작위세포내신호전도제이신사등중요생리공능,여농독증유발적급성폐손상、궤계통기후계발적호흡궤상관성폐손상등밀절상관.대NADPH양화매산생ROS적과정진행조공가능시방치급성폐손상적도경지일.본문근거최신연구진전,대NADPH양화매여급성폐손상적상관성진행종술.
The NADPH oxidase family composed of seven homologs,NOX1-5 and DUOX1/2,has emerged as an important source of reactive oxygen species (ROS).These members have distinct features in tissue distribution,expression regulation,and physiological functions.NOX-derived ROS exert bactericidal activities by oxidizing infected microorganisms,and also have been documented as intrinsic signaling molecules.Future studies will provide new insights into the role of NADPH oxidase family in the prevention of lung diseases.Here we review current understanding about NADPH oxidase family in normal lung physiology and their pathophysiologic roles in acute lung injury.
