中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
21期
2909-2910
,共2页
李辉%吴克义%陈家新%叶枝秀
李輝%吳剋義%陳傢新%葉枝秀
리휘%오극의%진가신%협지수
镇痛,患者控制%地佐辛%吗啡%罗哌卡因%麻醉,硬膜外%子宫切除术
鎮痛,患者控製%地佐辛%嗎啡%囉哌卡因%痳醉,硬膜外%子宮切除術
진통,환자공제%지좌신%마배%라고잡인%마취,경막외%자궁절제술
Analgesia,patient-controlled%Dezocine%Morphine%Ropivacaine%Anesthesia,epidural%Hysterec-tomy
目的 观察地佐辛复合罗哌卡因用于全子宫切除术后自控硬膜外镇痛(PCEA)的有效性和安全性.方法 选择择期妇科全子宫切除手术患者60例,随机均分为地佐辛复合罗哌卡因组(DR)和吗啡复合罗哌卡因组(MR)两组,两组镇痛药配置为:DR组0.225％盐酸罗哌卡因+0.005％地佐辛(100 ml)；MR组0.225％盐酸罗哌卡因+0.003％吗啡3 mg( 100 ml).术毕给予负荷量5ml镇痛泵复合液,开启PCA,背景剂量为2 ml/h,PCA为0.5 mL/次,锁定时间为15 min.分别记录两组术后1h、4h、8h、12 h、24 h、36 h、48 h的视觉模拟评分法(VAS法)、舒适度评分(BCS)、Ramsay镇静评分、PCEA有效按压次数及不良反应的发生情况.结果 两组术后各时间点VAS评分、BCS评分、Ramsay镇静评分、PCEA的有效按压次数组间比较均差异无统计学意义(均P＞0.05),DR组患者恶心、呕吐、瘙痒的发生率较MR组均显著降低(均P＜0.05).结论 地佐辛复合罗哌卡因用于全子宫切除术后自控硬膜外镇痛,安全有效,不良反应发生率低.
目的 觀察地佐辛複閤囉哌卡因用于全子宮切除術後自控硬膜外鎮痛(PCEA)的有效性和安全性.方法 選擇擇期婦科全子宮切除手術患者60例,隨機均分為地佐辛複閤囉哌卡因組(DR)和嗎啡複閤囉哌卡因組(MR)兩組,兩組鎮痛藥配置為:DR組0.225％鹽痠囉哌卡因+0.005％地佐辛(100 ml)；MR組0.225％鹽痠囉哌卡因+0.003％嗎啡3 mg( 100 ml).術畢給予負荷量5ml鎮痛泵複閤液,開啟PCA,揹景劑量為2 ml/h,PCA為0.5 mL/次,鎖定時間為15 min.分彆記錄兩組術後1h、4h、8h、12 h、24 h、36 h、48 h的視覺模擬評分法(VAS法)、舒適度評分(BCS)、Ramsay鎮靜評分、PCEA有效按壓次數及不良反應的髮生情況.結果 兩組術後各時間點VAS評分、BCS評分、Ramsay鎮靜評分、PCEA的有效按壓次數組間比較均差異無統計學意義(均P＞0.05),DR組患者噁心、嘔吐、瘙癢的髮生率較MR組均顯著降低(均P＜0.05).結論 地佐辛複閤囉哌卡因用于全子宮切除術後自控硬膜外鎮痛,安全有效,不良反應髮生率低.
목적 관찰지좌신복합라고잡인용우전자궁절제술후자공경막외진통(PCEA)적유효성화안전성.방법 선택택기부과전자궁절제수술환자60례,수궤균분위지좌신복합라고잡인조(DR)화마배복합라고잡인조(MR)량조,량조진통약배치위:DR조0.225％염산라고잡인+0.005％지좌신(100 ml)；MR조0.225％염산라고잡인+0.003％마배3 mg( 100 ml).술필급여부하량5ml진통빙복합액,개계PCA,배경제량위2 ml/h,PCA위0.5 mL/차,쇄정시간위15 min.분별기록량조술후1h、4h、8h、12 h、24 h、36 h、48 h적시각모의평분법(VAS법)、서괄도평분(BCS)、Ramsay진정평분、PCEA유효안압차수급불량반응적발생정황.결과 량조술후각시간점VAS평분、BCS평분、Ramsay진정평분、PCEA적유효안압차수조간비교균차이무통계학의의(균P＞0.05),DR조환자악심、구토、소양적발생솔교MR조균현저강저(균P＜0.05).결론 지좌신복합라고잡인용우전자궁절제술후자공경막외진통,안전유효,불량반응발생솔저.
Objective To observe the effect and safety of postoperative patient-controlled epidural analgesia with dezocine plus ropivacaine in patients underwent hysterectomy.Methods 60 patients,ASA Ⅰ ～ Ⅱ,undergoing hysterectomy operation.were randomly divided into two groups.0.225％ ropivacaine with 0.005％ dezocine ( DR group) or 0.225 ％ ropivacaine with 0.003％ morphine (MR group) were given epidurally after surgery,respectively,with an initial loading dose 5m l,basal dose of 2ml/h,PCA dose of 0.5ml and lockout time of 15 min.Visual analogue score(VAS),Bruggemann comfort scale(BCS),Ramsay sedation score(RSS),PCEA effective compression of the times and adverse effects were determined and compared at 1 h,4h,8h,12h,24h 36h and 48h after operation.PCEA effective compression of the number and incidence of adverse reactions were observed.Results There were no significant differences in VAS,BCS,RSS and PCEA effective compression of the times between two groups( all P ＞ 0.05 ).The percentage of nausea,vomiting and pruritus were significantly lower in group DR than that in group MR( all P ＜0.05).Conclusion Patient-controlled epidural analgesia with dezocine plus ropivacaine in patients underwent hysterectomy had analgesic effect and safety,with less advers eeffects.
