国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2010年
7期
483-485
,共3页
肿瘤抑制蛋白 p53%细胞凋亡%p53 凋亡刺激蛋白
腫瘤抑製蛋白 p53%細胞凋亡%p53 凋亡刺激蛋白
종류억제단백 p53%세포조망%p53 조망자격단백
Tumor suppressor protein p53%Apoptosis%Apoptosis stimutating protein of p53
p53凋亡刺激蛋白(ASPP)是p53的重要调节蛋白,其成员有ASPP1、ASPP2、iASPP.它们与p53形成复合物后,ASPP1和ASPP2特异性促进p53的细胞凋亡功能,而iASPP则同ASPP1和ASPP2竞争性地与p53结合位点结合,从而抑制p53的抑癌功能.ASPP家族尤其是iASPP有望成为肿瘤治疗的新靶点.
p53凋亡刺激蛋白(ASPP)是p53的重要調節蛋白,其成員有ASPP1、ASPP2、iASPP.它們與p53形成複閤物後,ASPP1和ASPP2特異性促進p53的細胞凋亡功能,而iASPP則同ASPP1和ASPP2競爭性地與p53結閤位點結閤,從而抑製p53的抑癌功能.ASPP傢族尤其是iASPP有望成為腫瘤治療的新靶點.
p53조망자격단백(ASPP)시p53적중요조절단백,기성원유ASPP1、ASPP2、iASPP.타문여p53형성복합물후,ASPP1화ASPP2특이성촉진p53적세포조망공능,이iASPP칙동ASPP1화ASPP2경쟁성지여p53결합위점결합,종이억제p53적억암공능.ASPP가족우기시iASPP유망성위종류치료적신파점.
The apoptosis stimulating proteins of p53 (ASPP) are important regulatory proteins of p53 family, consisting of ASPP1, ASPP2 and iASPP. ASPP combine with p53 ,and ASPP1 and ASPP2 promote cell apoptosis of p53 specifically,where as iASPP inhibit the tumor suppressing function of p53 by combining with p53. Thus,ASPP family of proteins,especially iASPP, may be a novel target for cancer therapy.
