国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2010年
2期
109-112
,共4页
吴洁莹%廖灿%许遵鹏%陈劲松%辜少玲%白雪%黎丽仙
吳潔瑩%廖燦%許遵鵬%陳勁鬆%辜少玲%白雪%黎麗仙
오길형%료찬%허준붕%진경송%고소령%백설%려려선
脐带血%供者%总有核细胞数%CD34+细胞
臍帶血%供者%總有覈細胞數%CD34+細胞
제대혈%공자%총유핵세포수%CD34+세포
Umbilical cord blood%donor%total nucleated cell%CD34+cell
目的 分析可能影响脐带血造血功能的供者特征.方法 对广州脐带血库1998年6月至2008年12月保存的4 358份脐带血的供者特征(包括母亲年龄、分娩方式、妊娠期、婴儿体重、婴儿性别)和脐带血采集量及造血功能的指标(包括总有核细胞数、CD34+细胞、干细胞集落等)进行相关性分析.结果 婴儿体重、分娩方式及婴儿性别是影响脐带血采集量、总有核细胞数、CD34+细胞数、CFUs及CFU-GM的主要因素.随着婴儿体重的增加,脐带血采集量、总有核细胞数、CD34+细胞数、CFUs、CFU-GM均呈上升趋势(P=0.000).阴道分娩时脐带血的采集量虽然低于刮宫产(P=0.000),但总有核细胞数、CD34+细胞数、CFUs,CFU-GM均高于剖宫产(P=0.000).女婴脐带血中总有核细胞数含量高于男婴(P=0.000),但脐带血采集量(P=0.000)、CD34+细胞数(P=0.002)均低于男婴.随着妊娠期的延长,脐带血中总有核细胞数增加(P=0.000),但CD34+细胞数减少(P=0.001).结论 某些脐带血供者特征对脐带血造血功能指标有积极影响.
目的 分析可能影響臍帶血造血功能的供者特徵.方法 對廣州臍帶血庫1998年6月至2008年12月保存的4 358份臍帶血的供者特徵(包括母親年齡、分娩方式、妊娠期、嬰兒體重、嬰兒性彆)和臍帶血採集量及造血功能的指標(包括總有覈細胞數、CD34+細胞、榦細胞集落等)進行相關性分析.結果 嬰兒體重、分娩方式及嬰兒性彆是影響臍帶血採集量、總有覈細胞數、CD34+細胞數、CFUs及CFU-GM的主要因素.隨著嬰兒體重的增加,臍帶血採集量、總有覈細胞數、CD34+細胞數、CFUs、CFU-GM均呈上升趨勢(P=0.000).陰道分娩時臍帶血的採集量雖然低于颳宮產(P=0.000),但總有覈細胞數、CD34+細胞數、CFUs,CFU-GM均高于剖宮產(P=0.000).女嬰臍帶血中總有覈細胞數含量高于男嬰(P=0.000),但臍帶血採集量(P=0.000)、CD34+細胞數(P=0.002)均低于男嬰.隨著妊娠期的延長,臍帶血中總有覈細胞數增加(P=0.000),但CD34+細胞數減少(P=0.001).結論 某些臍帶血供者特徵對臍帶血造血功能指標有積極影響.
목적 분석가능영향제대혈조혈공능적공자특정.방법 대엄주제대혈고1998년6월지2008년12월보존적4 358빈제대혈적공자특정(포괄모친년령、분면방식、임신기、영인체중、영인성별)화제대혈채집량급조혈공능적지표(포괄총유핵세포수、CD34+세포、간세포집락등)진행상관성분석.결과 영인체중、분면방식급영인성별시영향제대혈채집량、총유핵세포수、CD34+세포수、CFUs급CFU-GM적주요인소.수착영인체중적증가,제대혈채집량、총유핵세포수、CD34+세포수、CFUs、CFU-GM균정상승추세(P=0.000).음도분면시제대혈적채집량수연저우괄궁산(P=0.000),단총유핵세포수、CD34+세포수、CFUs,CFU-GM균고우부궁산(P=0.000).녀영제대혈중총유핵세포수함량고우남영(P=0.000),단제대혈채집량(P=0.000)、CD34+세포수(P=0.002)균저우남영.수착임신기적연장,제대혈중총유핵세포수증가(P=0.000),단CD34+세포수감소(P=0.001).결론 모사제대혈공자특정대제대혈조혈공능지표유적겁영향.
Objective To investigate whether the donors' characteristics would influence hematopoietic functional features of umbilical cord blood units (UCB).Method The study involved 4 358 UCBs which collected by Guangzhou Cord Blood Bank from June 1998 to December 2008.The donors' characteristics, such as mother's age, route of delivery, gestational age, birth weight of baby, sex of baby and UCB features including collected volume, total nucleated cells (TNC), CD34 + cells, CFUs and CFU- GM yields were analyzed.Results The birth weight of baby, route of delivery and sex of baby were the main factors which influenced the UCB features.The bigger babies had a greater volume, a higher TNC and CD34+cells and a better CFUs and CFU-GM yields (P=0.000).Cesarean section produced higher volume (P=0.000), but reduced TNC, CD34+cells, CFUs and CFU-GM yields compared to vaginal delivery (P =0.000).TNC was increased in Female babies (P=0.000), while volume (P=0.000) and CD34+cells (P=0.002) was incresed in male babies.A longer gestational age was associated with a higher TNC (P=0.000) and a lower CD34 + cells (P=0.001).Conclusion Some characteristics of UCB donors could influence UCB hematopoietic functional features.
