国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2011年
6期
568-571
,共4页
EBV%潜伏膜蛋白1%EBV核抗原1%EBV即刻早期基因
EBV%潛伏膜蛋白1%EBV覈抗原1%EBV即刻早期基因
EBV%잠복막단백1%EBV핵항원1%EBV즉각조기기인
Epstein-Barr virus%LMP1%EBNA1%BZLF1
Epstein-Barr病毒(Epsteir-Barr virus,EBV)属于疱疹病毒科γ亚科,与鼻咽癌、地方性伯基特淋巴瘤和霍奇金淋巴瘤等相关,是重要的肿瘤相关病毒.EBV基因组中存在多个多态性区域,根据这些区域中氨基酸的变异,可将EBV分为不同的亚型/变异株.目前,关于不同EBV亚型/变异株与疾病间是否相关尚无定论.该文从LMP1、EBNA1、BZLF1这三个多态性区域总结了近年来关于EBV亚型/变异株与疾病表型间关系的研究进展.
Epstein-Barr病毒(Epsteir-Barr virus,EBV)屬于皰疹病毒科γ亞科,與鼻嚥癌、地方性伯基特淋巴瘤和霍奇金淋巴瘤等相關,是重要的腫瘤相關病毒.EBV基因組中存在多箇多態性區域,根據這些區域中氨基痠的變異,可將EBV分為不同的亞型/變異株.目前,關于不同EBV亞型/變異株與疾病間是否相關尚無定論.該文從LMP1、EBNA1、BZLF1這三箇多態性區域總結瞭近年來關于EBV亞型/變異株與疾病錶型間關繫的研究進展.
Epstein-Barr병독(Epsteir-Barr virus,EBV)속우포진병독과γ아과,여비인암、지방성백기특림파류화곽기금림파류등상관,시중요적종류상관병독.EBV기인조중존재다개다태성구역,근거저사구역중안기산적변이,가장EBV분위불동적아형/변이주.목전,관우불동EBV아형/변이주여질병간시부상관상무정론.해문종LMP1、EBNA1、BZLF1저삼개다태성구역총결료근년래관우EBV아형/변이주여질병표형간관계적연구진전.
Epstein-Barr virus( EBV )is a ubiquitous human gamma-1 herpesvirus,which is associated with human malignancies,such as nasopharyngeal carcinoma,Burkitt's lymphoma and Hodgkin lymphoma.Based on the polymorphism of amino acids in the polymorphic region of EBV genome,it can be classified into different subtypes/variants.By now,whether the subtypes/variants of EBV preferentially is associated with particular malignancies or represent geographical polymorphism remains controversial.This review summarized the literature on sequence variation in EBV genes,focusing on LMP-1,EBNA-1,and BZLF-1 and their distribution by geography and disease.
