CAJ | 학술논문

目的探讨糖尿病视网膜病变严重程度与血清胆红素水平的关系.方法选取住院的2型糖尿病患者1062例,根据眼底检查结果分为无糖尿病视网膜病变(NDR)组457例、非增殖期糖尿病视网膜病变(NPDR)组484例、增殖期糖尿病视网膜病变(PDR)组121例.比较三组患者血清胆红素水平的差异.结果 PDR组患者血清总胆红素为(9.96±3.84)μmol/L,NPDR组患者血清总胆红素为(11.41±3.82)μmol/L,NDR组患者血清总胆红素为(13.38±3.98)μmol/L,三组间比较差异均有统计学意义(P＜0.01).多因素有序Logistic回归分析显示,血清总胆红素水平下降是糖尿病视网膜病变加重的独立危险因素.结论胆红素水平与糖尿病视网膜病变的发生、发展相关,应重视胆红素的抗氧化及抗炎作用.
목적 탐토당뇨병시망막병변엄중정도여혈청담홍소수평적관계.방법 선취주원적2형당뇨병환자1062례,근거안저검사결과분위무당뇨병시망막병변(NDR)조457례、비증식기당뇨병시망막병변(NPDR)조484례、증식기당뇨병시망막병변(PDR)조121례.비교삼조환자혈청담홍소수평적차이.결과 PDR조환자혈청총담홍소위(9.96±3.84)μmol/L,NPDR조환자혈청총담홍소위(11.41±3.82)μmol/L,NDR조환자혈청총담홍소위(13.38±3.98)μmol/L,삼조간비교차이균유통계학의의(P＜0.01).다인소유서Logistic회귀분석현시,혈청총담홍소수평하강시당뇨병시망막병변가중적독립위험인소.결론 담홍소수평여당뇨병시망막병변적발생、발전상관,응중시담홍소적항양화급항염작용.
Objective To investigate the relationship between the severity of diabetic retinopathy and serum bilirubin level. Methods From August 1 2008 to December 31 2009, hospitalized patients of 1062 cases with type 2 diabetes were divided into three groups according to fundus examination: no diabetic retinopathy (NDR) group (457 cases), non-proliferative diabetic retinopathy (NPDR) group (484 cases)and proliferative diabetic retinopathy (PDR) group ( 121 cases). The difference in serum bilirubin level was compared. Results Total bilirubin in PDR, NPDR and NDR group were (9.96 ± 3.84), ( 11.41 ± 3.82),( 13.38 ± 3.98) μ mol/L respectively. There was significant difference among three groups (P ＜ 0.01 ). Logistic multivariate regression analysis showed that a drop in serum total bilirubin level was an independent risk factor of diabetic retinopathy. Conclusions Bilirubin level and the severity of diabetic retinopathy have some relationship. The antioxidant bilirubin and anti-inflammatory effect should be paid attention to.