中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
11期
1086-1088
,共3页
邸书华%田祥%王培军%王云霞%王伟%甄利波
邸書華%田祥%王培軍%王雲霞%王偉%甄利波
저서화%전상%왕배군%왕운하%왕위%견리파
高脂血症%动脉粥样硬化%胆固醇%甘油三酯
高脂血癥%動脈粥樣硬化%膽固醇%甘油三酯
고지혈증%동맥죽양경화%담고순%감유삼지
Hyperlipidemia%Atherosclerosis%Cholesterol%Triglyceride
目的 研究联合应用国产苯扎贝特与氟伐他汀治疗混合型高脂血症的安全性反有效性.方法 选取180例混合性高脂血症患者随机分为两组,单药氟伐他汀组90例,给予氟伐他汀40mg,每晚1次,用药24周;联合治疗组90例,给予氟伐他汀40 mg,每晚1次,苯扎贝特200 mg,每日2次.观察24周.结果 两组均能使患者低密度脂蛋白胆固醇水平较治疗前降低,差异有统计学意义(均P<0.01),联合治疗组能够使患者甘油三酯下降,高密度脂蛋白胆固醇升高,差异亦有统计学意义(均P<0.05).结论 联合应用氟伐他汀40 mg+苯扎贝特400 mg治疗混合型高脂血症优于单用氟伐他汀治疗,并有良好的安全性.
目的 研究聯閤應用國產苯扎貝特與氟伐他汀治療混閤型高脂血癥的安全性反有效性.方法 選取180例混閤性高脂血癥患者隨機分為兩組,單藥氟伐他汀組90例,給予氟伐他汀40mg,每晚1次,用藥24週;聯閤治療組90例,給予氟伐他汀40 mg,每晚1次,苯扎貝特200 mg,每日2次.觀察24週.結果 兩組均能使患者低密度脂蛋白膽固醇水平較治療前降低,差異有統計學意義(均P<0.01),聯閤治療組能夠使患者甘油三酯下降,高密度脂蛋白膽固醇升高,差異亦有統計學意義(均P<0.05).結論 聯閤應用氟伐他汀40 mg+苯扎貝特400 mg治療混閤型高脂血癥優于單用氟伐他汀治療,併有良好的安全性.
목적 연구연합응용국산분찰패특여불벌타정치료혼합형고지혈증적안전성반유효성.방법 선취180례혼합성고지혈증환자수궤분위량조,단약불벌타정조90례,급여불벌타정40mg,매만1차,용약24주;연합치료조90례,급여불벌타정40 mg,매만1차,분찰패특200 mg,매일2차.관찰24주.결과 량조균능사환자저밀도지단백담고순수평교치료전강저,차이유통계학의의(균P<0.01),연합치료조능구사환자감유삼지하강,고밀도지단백담고순승고,차이역유통계학의의(균P<0.05).결론 연합응용불벌타정40 mg+분찰패특400 mg치료혼합형고지혈증우우단용불벌타정치료,병유량호적안전성.
Objective To evaluate the efficacy and safety of combination therapy with domestic bezafibrate and fluvastatin in patients with combined hyperlipidemia. Methods 180 patients with combined hyperlipidemia were randomly divided into two groups. They were assigned to receive 40 mg fluvastatin (n = 90) or a combination of 400 mg bezafibrate and 40 mg fluvastatin (n = 90) for 24 weeks. Results After 24 weeks treatments, the serum TC, LDL-C levels were reduced (P <0.01) and HDL-C level was increased more significantly (P <0.05) in the combi-nation therapy group. Conclusion Combination therapy with bezafibrate (400 mg) and fluvastatin (40 rag) is more effective than fluvastatin(40 mg) monotherapy.