中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
4期
447-450
,共4页
目的 探讨潜在危险因素对宫颈癌及癌前病变的影响.方法 收集本市三家市级医院确诊并尚未治疗过的宫颈癌92例、宫颈上皮内瘤样变Ⅲ级(即CINⅢ)63例及正常组252例,分析各因素与宫颈癌发病的关系.结果 单因素分析显示妇科疾病史(χ2＝19.31,P＜0.01)、月经初潮年龄(F＝11.62,P＜0.01)、首次性生活年龄(F＝25.76,P＜0.01)、首次生育年龄(F＝28.02,P＜0.01)、怀孕次数(F＝13.98,P＜0.01)、分娩次数(F＝4.78,P＜0.01)、文化程度(χ2＝10.70,P＜0.05)、HPV感染(χ2＝179.95,P＜0.01)、叶酸水平(F＝3.39,P＜0.05)(与宫颈癌及癌前病变的发生均有相关性(P＜0.05),而叶酸与维生素B12呈正相关相关系数r＝0.482,P＜0.05);Logistic回归显示经常饮茶(OR＝0.321,β＝-1.136,P＜0.05)、性生活后洗外生殖器的习惯(OR＝0.387,β＝-0.950,P＜0.05)、首次性生活年龄越迟(OR＝0.551,β＝0.596,P＜0.05)、体内叶酸水平越高(OR＝0.502,β＝-0.688,P＜0.01)是宫颈癌发病的保护因素;HPV感染(OR＝27.215,β＝3.304,P＜0.01)、分娩次数越多(OR＝1.846,β＝0.613,P＜0.05)及有被动吸烟史(OR＝1.673,β＝0.515,P＜0.05)则是宫颈癌发病的危险因素.结论 体内叶酸水平越高,宫颈癌的发病可能性越低,首次性生活年龄偏早、性生活后未洗外生殖器、HPV感染、多次孕产史及长期处于被动吸烟状态对宫颈癌的发病有影响,有饮茶习惯、补充叶酸及维生素B12可能有预防宫颈癌发病的作用.
目的 探討潛在危險因素對宮頸癌及癌前病變的影響.方法 收集本市三傢市級醫院確診併尚未治療過的宮頸癌92例、宮頸上皮內瘤樣變Ⅲ級(即CINⅢ)63例及正常組252例,分析各因素與宮頸癌髮病的關繫.結果 單因素分析顯示婦科疾病史(χ2＝19.31,P＜0.01)、月經初潮年齡(F＝11.62,P＜0.01)、首次性生活年齡(F＝25.76,P＜0.01)、首次生育年齡(F＝28.02,P＜0.01)、懷孕次數(F＝13.98,P＜0.01)、分娩次數(F＝4.78,P＜0.01)、文化程度(χ2＝10.70,P＜0.05)、HPV感染(χ2＝179.95,P＜0.01)、葉痠水平(F＝3.39,P＜0.05)(與宮頸癌及癌前病變的髮生均有相關性(P＜0.05),而葉痠與維生素B12呈正相關相關繫數r＝0.482,P＜0.05);Logistic迴歸顯示經常飲茶(OR＝0.321,β＝-1.136,P＜0.05)、性生活後洗外生殖器的習慣(OR＝0.387,β＝-0.950,P＜0.05)、首次性生活年齡越遲(OR＝0.551,β＝0.596,P＜0.05)、體內葉痠水平越高(OR＝0.502,β＝-0.688,P＜0.01)是宮頸癌髮病的保護因素;HPV感染(OR＝27.215,β＝3.304,P＜0.01)、分娩次數越多(OR＝1.846,β＝0.613,P＜0.05)及有被動吸煙史(OR＝1.673,β＝0.515,P＜0.05)則是宮頸癌髮病的危險因素.結論 體內葉痠水平越高,宮頸癌的髮病可能性越低,首次性生活年齡偏早、性生活後未洗外生殖器、HPV感染、多次孕產史及長期處于被動吸煙狀態對宮頸癌的髮病有影響,有飲茶習慣、補充葉痠及維生素B12可能有預防宮頸癌髮病的作用.
목적 탐토잠재위험인소대궁경암급암전병변적영향.방법 수집본시삼가시급의원학진병상미치료과적궁경암92례、궁경상피내류양변Ⅲ급(즉CINⅢ)63례급정상조252례,분석각인소여궁경암발병적관계.결과 단인소분석현시부과질병사(χ2＝19.31,P＜0.01)、월경초조년령(F＝11.62,P＜0.01)、수차성생활년령(F＝25.76,P＜0.01)、수차생육년령(F＝28.02,P＜0.01)、부잉차수(F＝13.98,P＜0.01)、분면차수(F＝4.78,P＜0.01)、문화정도(χ2＝10.70,P＜0.05)、HPV감염(χ2＝179.95,P＜0.01)、협산수평(F＝3.39,P＜0.05)(여궁경암급암전병변적발생균유상관성(P＜0.05),이협산여유생소B12정정상관상관계수r＝0.482,P＜0.05);Logistic회귀현시경상음다(OR＝0.321,β＝-1.136,P＜0.05)、성생활후세외생식기적습관(OR＝0.387,β＝-0.950,P＜0.05)、수차성생활년령월지(OR＝0.551,β＝0.596,P＜0.05)、체내협산수평월고(OR＝0.502,β＝-0.688,P＜0.01)시궁경암발병적보호인소;HPV감염(OR＝27.215,β＝3.304,P＜0.01)、분면차수월다(OR＝1.846,β＝0.613,P＜0.05)급유피동흡연사(OR＝1.673,β＝0.515,P＜0.05)칙시궁경암발병적위험인소.결론 체내협산수평월고,궁경암적발병가능성월저,수차성생활년령편조、성생활후미세외생식기、HPV감염、다차잉산사급장기처우피동흡연상태대궁경암적발병유영향,유음다습관、보충협산급유생소B12가능유예방궁경암발병적작용.
Objective To discuss about the relationship between the occurrence of the uterine cervix cancer and the risk factors.Methods Among the patients we collected,92 patients were diagnosed to have the cervical cancer,63 patients were diagnosed as CINⅢ (the cervical intraepithelial neoplasia,CIN),and 252 patients belonged to the control group.All patients had not been cured before.We used the questionnaire to investigate them about the dietary habit and other information.Through using different statistical Methods ,we explored the relationship between the cervical cancer and the potential factors.Results We found out that many factors contributed to the happening of the cervical cancer,such as gynecopathy(χ2=19.31,P＜0.01),the first time of the menses(F＝11.62,P＜0.01),the first time of the sex life(F＝25.76,P＜0.01),the first time of the parturition (F＝28.02,P＜0.01),the times of the pregnancy and the parturition(F1＝13.98,P1＜0.01;F2＝4.78,P2＜0.01),the culture degree(χ2＝10.70,P＜0.05),the infection of HPV(χ2＝179.95,P＜0.01),the level of the folic acid (F＝3.39,P＜0.05) and so on.The result of the logistic regression analysis showed that keeping the habit of drinking tea(OR＝0.321,β＝-1.136,P＜0.05),paying attention to the sanitation of the sex life(OR＝0.387,β＝-0.950,P＜0.05),putting off the first time of the sex life(OR＝0.551,β＝-0.596,P＜0.05),and the higher level of the folic acid (OR＝0.502,β＝-0.688,P＜0.05) were the protective factors tothe occurrence of the uterine cervix cancer.Meanwhile,the infection of the HPV(OR＝27.215,β＝3.304,P＜0.01),many times of the parturition(OR＝1.846,β＝0.613,P＜0.05) and the passive smoking (OR＝1.673,β＝0.515,P＜0.05) were the risk factors.Conclusions With the higher level of the folic acid,the less possibility you will get the cervical cancer.There exists many measures to prevent the happening of the cervical cancer,like keeping the healthy sex life,keeping far away from the passive smoking,not to give birth too early or too many and preventing being infected the HPV.What's more,having the good habit of drinking tea and paying attention to the supplement of the folic acid and Vitamin B12 may be the effective method to prevent the occurrence of the cervical cancer.
