中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2008年
35期
2487-2489
,共3页
多囊卵巢综合征%胰岛素%睾酮%函数曲线%自稳态
多囊卵巢綜閤徵%胰島素%睪酮%函數麯線%自穩態
다낭란소종합정%이도소%고동%함수곡선%자은태
Polycystic ovary syndrome%Insulin%Testosterone%Function curvilineAr%Homeostasis
目的 了解多囊卵巢综合征(PCOS)患者睾酮、胰岛素浓度之间动态量变关系.方法 97例PCOS患者以体块指数(MBI)等于25为界,分为肥胖(47例)和非肥胖组(50例);对照组为28名除外内分泌异常仅为输卵管因素不孕妇女.用统计软件SPSS的11种常用方程拟合建立睾酮和胰岛素动态量变关系并判断优化程度.结果 (1)PCOS肥胖、非肥胖组和对照组的睾酮与胰岛素(120 min)用Compound方程表达时相关性较佳,Rsq值分别为0.84、0.79和0.94.(2)3组数据对应的Compound函数曲线具有不同的参数值.结论 (1)Compound方程式是表达PCOS患者睾酮与胰岛素浓度之间存在量变关系的优化方程式.(2)机体对睾酮与胰岛素自稳态能力不同可能与Compound方程式参数不同有关.
目的 瞭解多囊卵巢綜閤徵(PCOS)患者睪酮、胰島素濃度之間動態量變關繫.方法 97例PCOS患者以體塊指數(MBI)等于25為界,分為肥胖(47例)和非肥胖組(50例);對照組為28名除外內分泌異常僅為輸卵管因素不孕婦女.用統計軟件SPSS的11種常用方程擬閤建立睪酮和胰島素動態量變關繫併判斷優化程度.結果 (1)PCOS肥胖、非肥胖組和對照組的睪酮與胰島素(120 min)用Compound方程錶達時相關性較佳,Rsq值分彆為0.84、0.79和0.94.(2)3組數據對應的Compound函數麯線具有不同的參數值.結論 (1)Compound方程式是錶達PCOS患者睪酮與胰島素濃度之間存在量變關繫的優化方程式.(2)機體對睪酮與胰島素自穩態能力不同可能與Compound方程式參數不同有關.
목적 료해다낭란소종합정(PCOS)환자고동、이도소농도지간동태량변관계.방법 97례PCOS환자이체괴지수(MBI)등우25위계,분위비반(47례)화비비반조(50례);대조조위28명제외내분비이상부위수란관인소불잉부녀.용통계연건SPSS적11충상용방정의합건립고동화이도소동태량변관계병판단우화정도.결과 (1)PCOS비반、비비반조화대조조적고동여이도소(120 min)용Compound방정표체시상관성교가,Rsq치분별위0.84、0.79화0.94.(2)3조수거대응적Compound함수곡선구유불동적삼수치.결론 (1)Compound방정식시표체PCOS환자고동여이도소농도지간존재량변관계적우화방정식.(2)궤체대고동여이도소자은태능력불동가능여Compound방정식삼수불동유관.
Objective To investigate the relationship of dynamic quantitative changes between insulin and testosterone in polycystic ovary syndrome (PCOS). Methods Peripheral blood samples were collected in the third to fifth day menstrual cycle from 97 PCOS patients, aged (24±6), 47 being obese (with BMI 25 kg/m2) and 50 being non-obese (with BMI≤25 kg/m2), and 27 women with oviductal sterility (control group). The serum testosterone was measured. All the subjects underwent oral glucose tolerance test (OGTT) with the glucose load of 75 g, and the plasma insulin levels 30, 60, 120, and 180 minutes later were measured. Curve fitting of 11 kinds of equations was used to estimate the optimization degree of relationship between testosterone and insulin. Results (1) The correlation between testosterone and insulin was the most perfect when the T and insulin levels 120 rain later of the obese and non-obese PCOS patients and the controls were expressed by Compound equation with the Rsq values of 0.84, 0.79, and 0.894 respectively. (2) The Compound function curves corresponding to the data of the 3 groups showed significantly different parameters. Conclusion (1) Compound equation is the opfmfized equation to express the quantitative change relationship between the testosterone and insulin levels in OCOS. (2) The difference in homeostasis ability to T and insulin may be related to the difference in the various parameters derived by Compound equation.
