CAJ | 학술논문

目的探讨乳腺癌VEGF,bFGF及其受体的表达特征和与微血管计数的关系.方法 SABC免疫组化法检测70例乳腺癌组织中VEGF,FLK-1,bFGF,FLG阳性系数值和MVC值,探讨其与腋窝淋巴结转移、临床病理特征之间的关系.结果腋窝淋巴结转移组VEHF,bFGF,FLK-1,和MVC值明显高于腋窝淋巴结未转移组,有非常显著性差异(P＜0.01).VEGF,FLK-1,FLG和MVC值临床分期0～Ⅱ期和Ⅲ～Ⅳ期组间有显著性或非常显著性差异(P＜0.05或P＜0.01).VEGF,bFGF表达与MVC的表达呈高度正相关,VEGF和bFGF,VEGF和FLK-1,bFGF和FLG表达呈相关.结论乳腺癌VEGF,bFGF及其受体与肿瘤血管生成、淋巴转移密切相关;VEGF,bFGF可以促进其受体的表达;VEGF的表达与bFGF高表达有关.
목적탐토유선암VEGF,bFGF급기수체적표체특정화여미혈관계수적관계.방법 SABC면역조화법검측70례유선암조직중VEGF,FLK-1,bFGF,FLG양성계수치화MVC치,탐토기여액와림파결전이、림상병리특정지간적관계.결과액와림파결전이조VEHF,bFGF,FLK-1,화MVC치명현고우액와림파결미전이조,유비상현저성차이(P＜0.01).VEGF,FLK-1,FLG화MVC치림상분기0～Ⅱ기화Ⅲ～Ⅳ기조간유현저성혹비상현저성차이(P＜0.05혹P＜0.01).VEGF,bFGF표체여MVC적표체정고도정상관,VEGF화bFGF,VEGF화FLK-1,bFGF화FLG표체정상관.결론유선암VEGF,bFGF급기수체여종류혈관생성、림파전이밀절상관;VEGF,bFGF가이촉진기수체적표체;VEGF적표체여bFGF고표체유관.
Objective:To study the expression of VEGF, bFGF, FLK-1 and their receptors and the relation with microvascular counts (MVC) in patients with breast cancer.Methods:Immunohistochemical methods (SABC) was used to study the expression of VEGF, FLK-1, bFGF, FLG and MVC on paraffin-embeded sections in 70 cases of patients with breast cancer.Results:The mean of VEGF, FLK-1, bFGF, FLG and MVC in cases of axillary lymph node metastasis group were higher than that in ones without axillary lymph node metastasis group (P＜0.01). There were significant or high significant difference between the mean of VEGF, FLK-1, bFGF, FLG and MVC in cases of stage 0～Ⅱ and that in cases of stage Ⅲ～Ⅳ (P＜0.05 or P＜0.01).The close correlations were found among the expression of VEGF, bFGF, and the mean of MVC.The expression of VEGF and bFGF, VEGF, and FLK-1, bFGF and FLG were also correlated.Conclusions:VEGF, bFGF and their receptor might be highly related to angiogenesis and lymph metastasis in patients with breast cancer.VEGF and bFGF could upregulate the expression of their receptor, the expression of VEGF was related to bFGF over-expressions.