中国现代医学杂志
中國現代醫學雜誌
중국현대의학잡지
CHINA JOURNAL OF MODERN MEDICINE
2004年
15期
39-42
,共4页
张新友%张大龙%吴铭%徐肇明%王伏田
張新友%張大龍%吳銘%徐肇明%王伏田
장신우%장대룡%오명%서조명%왕복전
急性单核细胞白血病(M5亚型)%临床分析
急性單覈細胞白血病(M5亞型)%臨床分析
급성단핵세포백혈병(M5아형)%림상분석
acute monocytic leukemia (M5 subtype)%clinical analysis
目的探讨急性髓系白血病M5亚型(AML-M5)的临床特点,以提高对M5亚型的认识.方法回顾性分析1995年1月~2002年10月38例初发AML-M5的临床资料.结果与M2亚型相比,M5亚型的发病年龄大10岁左右,发病时肝、脾、淋巴结肿大及牙龈肿胀较多;高白细胞性急性白血病(HAL)发生率为47.4%,早期病死率是26.3%(明显高于M2亚型的14.7%和5.9%);完全缓解率61.1%,但短期内复发死亡率高,3年无病生存率仅7.7%(明显低于M2亚型的26.3%).结论M5亚型发病年龄大,HAL发生率高,髓外浸润严重,治疗难度大,预后恶劣.
目的探討急性髓繫白血病M5亞型(AML-M5)的臨床特點,以提高對M5亞型的認識.方法迴顧性分析1995年1月~2002年10月38例初髮AML-M5的臨床資料.結果與M2亞型相比,M5亞型的髮病年齡大10歲左右,髮病時肝、脾、淋巴結腫大及牙齦腫脹較多;高白細胞性急性白血病(HAL)髮生率為47.4%,早期病死率是26.3%(明顯高于M2亞型的14.7%和5.9%);完全緩解率61.1%,但短期內複髮死亡率高,3年無病生存率僅7.7%(明顯低于M2亞型的26.3%).結論M5亞型髮病年齡大,HAL髮生率高,髓外浸潤嚴重,治療難度大,預後噁劣.
목적탐토급성수계백혈병M5아형(AML-M5)적림상특점,이제고대M5아형적인식.방법회고성분석1995년1월~2002년10월38례초발AML-M5적림상자료.결과여M2아형상비,M5아형적발병년령대10세좌우,발병시간、비、림파결종대급아간종창교다;고백세포성급성백혈병(HAL)발생솔위47.4%,조기병사솔시26.3%(명현고우M2아형적14.7%화5.9%);완전완해솔61.1%,단단기내복발사망솔고,3년무병생존솔부7.7%(명현저우M2아형적26.3%).결론M5아형발병년령대,HAL발생솔고,수외침윤엄중,치료난도대,예후악렬.
Objective: To enhance the understanding of the clinical characteristics of M5. Methods: The clinical data of 38 patients with primary AML-M5 from January, 1995 to October, 2002 was analyzed with systemic retrospective methods. Results: The suffering age of M5, subtype was ten-year older than that of M2subtype. Hepatomegaly, splenomegaly, lymphadenopathy, gingival swelling and hyperleukocyric acute leukemia (HAL) were more frequent in M5 subtype. The early mortality rate significantly increased in M5 subtype (26.3%) compared with M2 subtype (5.9%). Complete remission rate of M5 subtype was 61.1%, recurrence cases were more in short-period. 3-year free disease survival rate in M5 subtype was 7.7%, which was lower than that of M2 subtype (26.3%). Conclusion: This specific subtype of AML has significant extramedullary infiltration, higher early mortality, more refractory treatment and poorer prognosis.