CAJ | 학술논문

目的:探讨头颅CT未显示脑白质变性的轻度认知损害(MCI)患者的事件相关电位(ERP)P300、脑电图(EEG)和血浆载脂蛋白B的特点,为早期血管性痴呆的诊断提供帮助.方法:对60例MCI患者行头颅CT检查,根据有无脑室周围、半卵圆区、皮质下白质斑片状影,将上述患者分为脑白质变性组及非脑白质变性组,均进行P300、EEG及血浆载脂蛋白B检查,进行相关性分析,并与健康老年组32例做比较.结果:脑白质变性组与非脑白质变性组P300检查比较,P300峰潜伏期有显著延长,部分非脑白质变性患者P300峰潜伏期有轻度延长,与健康组相比有显著差异:脑电图检查,脑白质变性组以δ、θ波为主,轻-中度异常比例显著高于非脑白质变性组,非脑白质变性组以α、β波为主:健康老年组以α波为主;血浆载脂蛋白B化验,各组之间无显著差异.结论:P300潜伏期延长提示MCI患者可能有早期血管性痴呆;EEG颞部θ波增多提示MCI患者可能有早期血管性痴呆.载脂蛋白B化验未见明显差异,在本次研究中对于早期血管性痴呆诊断无确切临床意义.
목적:탐토두로CT미현시뇌백질변성적경도인지손해(MCI)환자적사건상관전위(ERP)P300、뇌전도(EEG)화혈장재지단백B적특점,위조기혈관성치태적진단제공방조.방법:대60례MCI환자행두로CT검사,근거유무뇌실주위、반란원구、피질하백질반편상영,장상술환자분위뇌백질변성조급비뇌백질변성조,균진행P300、EEG급혈장재지단백B검사,진행상관성분석,병여건강노년조32례주비교.결과:뇌백질변성조여비뇌백질변성조P300검사비교,P300봉잠복기유현저연장,부분비뇌백질변성환자P300봉잠복기유경도연장,여건강조상비유현저차이:뇌전도검사,뇌백질변성조이δ、θ파위주,경-중도이상비례현저고우비뇌백질변성조,비뇌백질변성조이α、β파위주:건강노년조이α파위주;혈장재지단백B화험,각조지간무현저차이.결론:P300잠복기연장제시MCI환자가능유조기혈관성치태;EEG섭부θ파증다제시MCI환자가능유조기혈관성치태.재지단백B화험미견명현차이,재본차연구중대우조기혈관성치태진단무학절림상의의.
Objective: To explore the characteristics of P300, electroencephalography (EEG) and apoprotein B in elderly pa tients with mild cognitive impairment (MCl),who had not myelinopathy in CT. Methods: The subjects were 60 cases with MCI. They were divided into 2 groups according to whether or not myelinopathy,and compare with 32 healthy elderly as control. The P300, EEG and apoprotein B were recorded from each subject. Do the correlation analysis. Results: As to the parame-ters of P300,the difference between myelinopathy and non- myelinopathy was prolonged latent phase (P<0.05). The latency of the part of non- myelinopathy group prolonged slightly. Compared with the healthy group, there was significant deviation (P<0.05). The EEG of the myelinopathy group was mainly expressed in δ-wave and θ-wave. The EEG of the non-myelinopathy group was mainly expressed in α-wave and β-wave. The EEG of the healthy group was mainly expressed in α-wave. As to the apoprotein B, there was no difference in each group. Conclusion: The patients with mild cognitive im-pairment who have prolonged latent phase may convert to pristine vascular dementia. The increase of θ-wave in the pars temporalis may indicate pristine vascular dementia. Apoprotein B has no clinical significance for the diagnosis of pristine vascular dementia.