CAJ | 학술논문

目的:评价血浆N末端B型利钠肽原(NT-proBNP)对急性冠脉综合征(ACS)患者近期预后的预测价值.方法:连续检测600例住院的ACS患者的血浆NT-proBNP浓度.依据住院期间患者有无心血管事件(心源性死亡、心源性休克、充血性心力衰竭)分为事件组(108例)和无事件组(n＝492例),比较两组NT-proBNP水平,并用回归分析法判断血浆NT-proBNP是否为ACS患者近期心血管事件的独立预测因素.结果:事件组血浆NT-proBNP浓度显著高于无事件组[1361.2(965.3,2088.6)pmol/L比605.7(274.5,1177.8)pmol/L,P＜0.01].Logistic多元逐步回归分析表明,血浆NT-proBNP是ACS患者近期发生心血管事件的独立预测因素(OR=1.000,P=0.000).结论:入院时血浆N末端B型利钠肽原是急性冠脉综合征患者近期预后的独立预测因素.
목적:평개혈장N말단B형리납태원(NT-proBNP)대급성관맥종합정(ACS)환자근기예후적예측개치.방법:련속검측600례주원적ACS환자적혈장NT-proBNP농도.의거주원기간환자유무심혈관사건(심원성사망、심원성휴극、충혈성심력쇠갈)분위사건조(108례)화무사건조(n＝492례),비교량조NT-proBNP수평,병용회귀분석법판단혈장NT-proBNP시부위ACS환자근기심혈관사건적독립예측인소.결과:사건조혈장NT-proBNP농도현저고우무사건조[1361.2(965.3,2088.6)pmol/L비605.7(274.5,1177.8)pmol/L,P＜0.01].Logistic다원축보회귀분석표명,혈장NT-proBNP시ACS환자근기발생심혈관사건적독립예측인소(OR=1.000,P=0.000).결론:입원시혈장N말단B형리납태원시급성관맥종합정환자근기예후적독립예측인소.
Objective:To evaluate the predictive value of plasma amino-terminal pro-B-type natriuretic peptide (NTproBNP) on short term prognosis in patients with acute coronary syndrome (ACS).Methods:Plasma NT-proBNP levels were measured in ACS patients within 24 h after admission with ELISA method.The 600 ACS patients were divided into two groups:event group (n=108) and no-event group (n=492) according to occurrence of cardiovascular events (including cardiac death,cardiac shock and heart failure).The NT-proBNP levels were compared between two groups.Single factor and multiple factor Logistic regression analyses were used to evaluate if NT-proBNP was an independent predictor for short term prognosis.Results:The plasma NT-proBNP levels of event group were significantly higher than those of no-event group [1361.2 (965.3,2088.6) pmol/L vs.605.7(274.5,1177.8)pmol/L,P＜0.01].Multiplefactor Logistic regression analyses demonstrated that plasma NT-proBNP was an independent predictor for short term prognosis (OR=1.000,P＜0.01) in ACS patients.Conclusion:Plasma NT-proBNP was an independent predictor for short term prognosis in ACS patients.