CAJ | 학술논문

癫(癎)耐药机制的研究已引起越来越多人的重视.P-糖蛋白(P-glycoprotein,Pgp)是近年来研究的热点之一,在体内主要起转运作用,其编码基因的多态性也影响着它的表达.该文从Pgp的编码基因多态性、多药转运蛋白假说、浓度平衡转运学说、Pgp抑制后效应方面就Pgp与癫(癎)耐药的相关性进行综述.
전(간)내약궤제적연구이인기월래월다인적중시.P-당단백(P-glycoprotein,Pgp)시근년래연구적열점지일,재체내주요기전운작용,기편마기인적다태성야영향착타적표체.해문종Pgp적편마기인다태성、다약전운단백가설、농도평형전운학설、Pgp억제후효응방면취Pgp여전(간)내약적상관성진행종술.
The research of epilepsy drug-resistant mechanism has been paid more and more attention. Pglycoprotein(Pgp) ,being one of the hot points of recent research,plays the transporting role in the body,and its coding genetic polymorphism also affects its expression. The relationship between Pgp and drug-resistant epilepsy is reviewed based on the coding genetic polymorphisms, multidrug transporters hypothesis, concentration equilibrium transport assay, and Pgp inhibition effect.