中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
8期
680-683
,共4页
明庆森%姚树桥%张芸%陈海燕
明慶森%姚樹橋%張蕓%陳海燕
명경삼%요수교%장예%진해연
外化性行为%单胺氧化酶A基因%儿童期虐待%调节效应
外化性行為%單胺氧化酶A基因%兒童期虐待%調節效應
외화성행위%단알양화매A기인%인동기학대%조절효응
Externalizing behavior%Monoamine oxidase A gene%Childhood abuse%Moderating effort
目的 探讨男性青少年的儿童期虐待与外化性行为的关系以及单胺氧化酶A (MAOA)基因启动子区域可变重复序列(VNTR)多态性对其关系的调节作用.方法 采用随机整群抽样法抽取长沙352名汉族男性中学生,用Achenbach儿童行为量表-青少年自我报告表(CBCL-YSR)和儿童期虐待问卷(CTQ-SF)对其进行测评,并鉴定其MAOA基因型.运用分层回归分析检验调节效应.结果 (1)MAOA 基因高活性与低活性两型被试在年龄[ (15.82±1.52)岁,(15.94±1.62)岁]、外化性行为[(15.13±10.14)分,(14.33±9.70)分]、虐待总分[(52.59±10.46)分,(51.39 ±7.56)分]、情感虐待[(7.63±3.31)分,(7.11±2.68)分]、躯体虐待[(6.40±2.82)分,(6.12±2.05)分]、性虐待[(6.42±3.24)分,(5.94±1.72)分]、情感忽视[(13.44±5.12)分,(13.16 ±4.83)分]及躯体忽视得分[(10.27±2.64)分,(10.44±2.53)分]上差异均无统计学意义(t=-1.789～0.678,P＞0.05).(2)除情感忽视及躯体忽视外,情感虐待、躯体虐待、性虐待对外化性行为均有显著预测作用(Sβ=0.141 ～0.347,P＜0.01).(3)MAOA基因不能直接影响外化性行为(Sβ=-0.023,P＞0.05);MAOA基因与情感虐待交互作用有统计学意义(Sβ=-0.148,P＜0.01),与躯体虐待、性虐待交互作用无统计学意义(Sβ=- 0.067,-0.005,P ＞0.05).结论 MAOA基因多态性在男性青少年儿童期情感虐待与外化性行为的关系间起调节作用.
目的 探討男性青少年的兒童期虐待與外化性行為的關繫以及單胺氧化酶A (MAOA)基因啟動子區域可變重複序列(VNTR)多態性對其關繫的調節作用.方法 採用隨機整群抽樣法抽取長沙352名漢族男性中學生,用Achenbach兒童行為量錶-青少年自我報告錶(CBCL-YSR)和兒童期虐待問捲(CTQ-SF)對其進行測評,併鑒定其MAOA基因型.運用分層迴歸分析檢驗調節效應.結果 (1)MAOA 基因高活性與低活性兩型被試在年齡[ (15.82±1.52)歲,(15.94±1.62)歲]、外化性行為[(15.13±10.14)分,(14.33±9.70)分]、虐待總分[(52.59±10.46)分,(51.39 ±7.56)分]、情感虐待[(7.63±3.31)分,(7.11±2.68)分]、軀體虐待[(6.40±2.82)分,(6.12±2.05)分]、性虐待[(6.42±3.24)分,(5.94±1.72)分]、情感忽視[(13.44±5.12)分,(13.16 ±4.83)分]及軀體忽視得分[(10.27±2.64)分,(10.44±2.53)分]上差異均無統計學意義(t=-1.789～0.678,P＞0.05).(2)除情感忽視及軀體忽視外,情感虐待、軀體虐待、性虐待對外化性行為均有顯著預測作用(Sβ=0.141 ～0.347,P＜0.01).(3)MAOA基因不能直接影響外化性行為(Sβ=-0.023,P＞0.05);MAOA基因與情感虐待交互作用有統計學意義(Sβ=-0.148,P＜0.01),與軀體虐待、性虐待交互作用無統計學意義(Sβ=- 0.067,-0.005,P ＞0.05).結論 MAOA基因多態性在男性青少年兒童期情感虐待與外化性行為的關繫間起調節作用.
목적 탐토남성청소년적인동기학대여외화성행위적관계이급단알양화매A (MAOA)기인계동자구역가변중복서렬(VNTR)다태성대기관계적조절작용.방법 채용수궤정군추양법추취장사352명한족남성중학생,용Achenbach인동행위량표-청소년자아보고표(CBCL-YSR)화인동기학대문권(CTQ-SF)대기진행측평,병감정기MAOA기인형.운용분층회귀분석검험조절효응.결과 (1)MAOA 기인고활성여저활성량형피시재년령[ (15.82±1.52)세,(15.94±1.62)세]、외화성행위[(15.13±10.14)분,(14.33±9.70)분]、학대총분[(52.59±10.46)분,(51.39 ±7.56)분]、정감학대[(7.63±3.31)분,(7.11±2.68)분]、구체학대[(6.40±2.82)분,(6.12±2.05)분]、성학대[(6.42±3.24)분,(5.94±1.72)분]、정감홀시[(13.44±5.12)분,(13.16 ±4.83)분]급구체홀시득분[(10.27±2.64)분,(10.44±2.53)분]상차이균무통계학의의(t=-1.789～0.678,P＞0.05).(2)제정감홀시급구체홀시외,정감학대、구체학대、성학대대외화성행위균유현저예측작용(Sβ=0.141 ～0.347,P＜0.01).(3)MAOA기인불능직접영향외화성행위(Sβ=-0.023,P＞0.05);MAOA기인여정감학대교호작용유통계학의의(Sβ=-0.148,P＜0.01),여구체학대、성학대교호작용무통계학의의(Sβ=- 0.067,-0.005,P ＞0.05).결론 MAOA기인다태성재남성청소년인동기정감학대여외화성행위적관계간기조절작용.
Objective To explore the relationship between male adolescents' childhood abuse and externalizing behaviors,and the moderating effect of monoamine oxidase A (MAOA) gene promoter region variable number tandem repeat (VNTR) polymorphism.Methods Through random cluster sampling,352 Han male middle school students from Changsha were tested by Achenbach child behavior checklist-youth self reports (CBCL-YSR)and childhood trauma questionnaire-28 item short form (CTQ-SF),their MAOA genotypes were also identified.A hierarchical multiple regression analysis was used to test the moderating effect.Results ( 1 ) Compared participates with high activity MAOA gene and that with low activity MAOA gene,there were no significant differences on age ( ( 15.82 ± 1.52) vs ( 15.94 ± 1.62 ) ),externalizing behaviors ( ( 15.13 ± 10.14 ) vs ( 14.33 ± 9.70 ) ),total abuse ( (52.59 ± 10.46) vs (51.39 ± 7.56 ) ),emotional abuse( ( 7.63 ± 3.31 ) vs ( 7.11 ± 2.68 ) ),physical abuse ( ( 6.40 ± 2.82) vs (6.12 ± 2.05 ) ),sexual abuse ( ( 6.42 ± 3.24 ) vs ( 5.94 ± 1.72 ) ),emotional neglect ((13.44±5.12) vs (13.16 ±4.83) ),physical neglect( (10.27 ±2.64) vs (10.44±2.53))(t=-1.789～0.678,P ＞ 0.05 ).(2)Except emotional neglect and physical neglect,emotional abuse,physical abuse and sexual abuse could predict externalizing behaviors( Sβ =0.141 ～0.347,P ＜ 0.01 ).(3) MAOA gene was not directly related to externalizing behaviors( Sβ =- 0.023,P ＞ 0.05 ).There was a significant interaction between MAOA gene and emotional abuse( Sβ =-0.148,P ＜ 0.01 ).The interaction between MAOA gene and physical abuse or sexual abuse showed no statistical significance( Sβ =- 0.067,- 0.005,P ＞ 0.05 ).Conclusion MAOA gene polymorphism can moderate the relationship between male adolescents'childhood emotional abuse and externalizing behaviors.
