国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2009年
6期
351-353
,共3页
何建华%喻文才%张顺琼%曾钦文
何建華%喻文纔%張順瓊%曾欽文
하건화%유문재%장순경%증흠문
甲状腺功能亢进症%碘放射性同位素%近距离放射疗法
甲狀腺功能亢進癥%碘放射性同位素%近距離放射療法
갑상선공능항진증%전방사성동위소%근거리방사요법
Hyperthyroidism%Radioiodine%Brachytherapy
目的 比较~(131)I固定剂量法和计算剂量法治疗甲亢的近期疗效.方法 148例甲亢患者随机分配为固定剂量组和计算剂量组,~(131)I治疗后6个月随访,检测患者血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT_3)和游离甲状腺素(FT_4)水平,评价~(131)I治疗效果.结果 ~(131)I治疗后6个月固定剂量组、计算剂量组甲减发生率分别为31.1%、28.4%,统计学差异无意义(χ~2=0.742.P=0.528),总治愈率分别为93.3%、85.2%,统计学差异无意义(χ~2=0.958,P=0.403).不同治疗结果(甲亢、甲状腺功能正常和甲减)之间甲状腺质量的统计学差异有意义(F=13.639,P=0.000),患者年龄、24h甲状腺吸碘率(RAIU)统计学差异无意义(F=1.374,P=0.241;F=2.534,P=0.137).结论 ~(131)I固定剂量法简化治疗步骤,节约治疗费用,是值得提倡的治疗方法.
目的 比較~(131)I固定劑量法和計算劑量法治療甲亢的近期療效.方法 148例甲亢患者隨機分配為固定劑量組和計算劑量組,~(131)I治療後6箇月隨訪,檢測患者血清促甲狀腺激素(TSH)、遊離三碘甲腺原氨痠(FT_3)和遊離甲狀腺素(FT_4)水平,評價~(131)I治療效果.結果 ~(131)I治療後6箇月固定劑量組、計算劑量組甲減髮生率分彆為31.1%、28.4%,統計學差異無意義(χ~2=0.742.P=0.528),總治愈率分彆為93.3%、85.2%,統計學差異無意義(χ~2=0.958,P=0.403).不同治療結果(甲亢、甲狀腺功能正常和甲減)之間甲狀腺質量的統計學差異有意義(F=13.639,P=0.000),患者年齡、24h甲狀腺吸碘率(RAIU)統計學差異無意義(F=1.374,P=0.241;F=2.534,P=0.137).結論 ~(131)I固定劑量法簡化治療步驟,節約治療費用,是值得提倡的治療方法.
목적 비교~(131)I고정제량법화계산제량법치료갑항적근기료효.방법 148례갑항환자수궤분배위고정제량조화계산제량조,~(131)I치료후6개월수방,검측환자혈청촉갑상선격소(TSH)、유리삼전갑선원안산(FT_3)화유리갑상선소(FT_4)수평,평개~(131)I치료효과.결과 ~(131)I치료후6개월고정제량조、계산제량조갑감발생솔분별위31.1%、28.4%,통계학차이무의의(χ~2=0.742.P=0.528),총치유솔분별위93.3%、85.2%,통계학차이무의의(χ~2=0.958,P=0.403).불동치료결과(갑항、갑상선공능정상화갑감)지간갑상선질량적통계학차이유의의(F=13.639,P=0.000),환자년령、24h갑상선흡전솔(RAIU)통계학차이무의의(F=1.374,P=0.241;F=2.534,P=0.137).결론 ~(131)I고정제량법간화치료보취,절약치료비용,시치득제창적치료방법.
Objective To compare clinical efficacy of ~(131)I treatment for hyperthyroidism between fixed dose and calculated dose methods.Methods One hundred and forty eight patients with hyperthyroidism were randomly allocated fixed dose and calculated dose groups.Follow up was done 6months post therapy,serum free triiodothyronine(FT_3),free thyroxin(FT_4)and thyroid stimulating hormone(TSH)were measured and following clinical outcome was monitored.Results The occurrence of hypothyroidism 6 months after ~(131)I treatment in fixed dose and calcuhted dose groups was 31.1% and 28.4%respectively.There was no distinct difference between them(χ~2=0.742,P=0.528).The cure rate was 93.3%and 85.2% respectively.There was no distinct difference between them(χ~2=0.958,P=0.403).A good correlation was between clinical efficacy and thyroid mass(F=13.639,P=0.000).There was no distinct difference between the two groups of ages and 24h radioactive iodine uptake(F=1.374,P=0.241;F=2.534,P=0.137).Conclusion The use of a fixed dose metllod simplifies the approach to treatment with potential cost savings.
