中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2008年
8期
718-721
,共4页
傅路红%YE Ping-xian%孙志凌%XIANG Yan-fang%朱献忠
傅路紅%YE Ping-xian%孫誌凌%XIANG Yan-fang%硃獻忠
부로홍%YE Ping-xian%손지릉%XIANG Yan-fang%주헌충
高血压%肥大,左心室,运动试验%呼吸功能试验
高血壓%肥大,左心室,運動試驗%呼吸功能試驗
고혈압%비대,좌심실,운동시험%호흡공능시험
Hypertension%Hypertrophy,left ventricular%Exercise tests%Respiratory functiontests
目的 评估高血压及伴左心室肥厚(LVH)患者心肺运动功能改变并探讨LVH对心脏贮备功能的影响.方法 对70例原发性高血压(EH)患者根据超声心动图测定的左心室质量指数(LVMI)分为LVH组和非LVH组,选健康体检者为对照组.应用内置同步12导联心电图的运动心肺功能仪测定和比较各组在分级递增运动后达无氧阈(AT)和最大摄氧量(VO2max)时的代谢当量(METs),摄氧量(VO2),公斤体重摄氧量(VO2/kg),和每搏摄氧量(VO2/HR).结果 (1)在达AT值时,EH并LVH组和非LVH组METs和VO2/kg均低于对照组[METs:3.57±0.8和4.34±1.47比5.21±1.45,P<0.01;VO2/kg:(12.38±2.85)ml·min-1·kg-1和(14.42±4.33)ml·min-1·kg-1比(18.48±4.52)ml·min-1·kg-1,P<0.01],EH并LVH组的降低较非LVH组差异也有统计学意义(P<0.05).(2)在VO2max时,EH并LVH组和非LVH组METs和VO2/kg均低于对照组[METs:4.94±1.24和5.90±1.51比6.96±1.85;VO2/kg:(17.20±4.34)ml·min-1·kg-1和(20.41±4.59)ml·min-1·kg-1比(24.04±5.21)ml·min-1·kg-1,P均<0.01],EH并LVH组的降低较非LVH组差异也有统计学意义(P<0.05).(3)经相关分析显示,EH并LVH组LVMI与VO2/kg呈显著负相关(在AT值R=-0.40,在VO2max值R=-0.31,P<0.01).结论 EH患者心肺运动指标METs和VO2/kg降低,运动耐量受损,并与LVMI增高相关.提示EH患者心脏贮备功能下降.
目的 評估高血壓及伴左心室肥厚(LVH)患者心肺運動功能改變併探討LVH對心髒貯備功能的影響.方法 對70例原髮性高血壓(EH)患者根據超聲心動圖測定的左心室質量指數(LVMI)分為LVH組和非LVH組,選健康體檢者為對照組.應用內置同步12導聯心電圖的運動心肺功能儀測定和比較各組在分級遞增運動後達無氧閾(AT)和最大攝氧量(VO2max)時的代謝噹量(METs),攝氧量(VO2),公斤體重攝氧量(VO2/kg),和每搏攝氧量(VO2/HR).結果 (1)在達AT值時,EH併LVH組和非LVH組METs和VO2/kg均低于對照組[METs:3.57±0.8和4.34±1.47比5.21±1.45,P<0.01;VO2/kg:(12.38±2.85)ml·min-1·kg-1和(14.42±4.33)ml·min-1·kg-1比(18.48±4.52)ml·min-1·kg-1,P<0.01],EH併LVH組的降低較非LVH組差異也有統計學意義(P<0.05).(2)在VO2max時,EH併LVH組和非LVH組METs和VO2/kg均低于對照組[METs:4.94±1.24和5.90±1.51比6.96±1.85;VO2/kg:(17.20±4.34)ml·min-1·kg-1和(20.41±4.59)ml·min-1·kg-1比(24.04±5.21)ml·min-1·kg-1,P均<0.01],EH併LVH組的降低較非LVH組差異也有統計學意義(P<0.05).(3)經相關分析顯示,EH併LVH組LVMI與VO2/kg呈顯著負相關(在AT值R=-0.40,在VO2max值R=-0.31,P<0.01).結論 EH患者心肺運動指標METs和VO2/kg降低,運動耐量受損,併與LVMI增高相關.提示EH患者心髒貯備功能下降.
목적 평고고혈압급반좌심실비후(LVH)환자심폐운동공능개변병탐토LVH대심장저비공능적영향.방법 대70례원발성고혈압(EH)환자근거초성심동도측정적좌심실질량지수(LVMI)분위LVH조화비LVH조,선건강체검자위대조조.응용내치동보12도련심전도적운동심폐공능의측정화비교각조재분급체증운동후체무양역(AT)화최대섭양량(VO2max)시적대사당량(METs),섭양량(VO2),공근체중섭양량(VO2/kg),화매박섭양량(VO2/HR).결과 (1)재체AT치시,EH병LVH조화비LVH조METs화VO2/kg균저우대조조[METs:3.57±0.8화4.34±1.47비5.21±1.45,P<0.01;VO2/kg:(12.38±2.85)ml·min-1·kg-1화(14.42±4.33)ml·min-1·kg-1비(18.48±4.52)ml·min-1·kg-1,P<0.01],EH병LVH조적강저교비LVH조차이야유통계학의의(P<0.05).(2)재VO2max시,EH병LVH조화비LVH조METs화VO2/kg균저우대조조[METs:4.94±1.24화5.90±1.51비6.96±1.85;VO2/kg:(17.20±4.34)ml·min-1·kg-1화(20.41±4.59)ml·min-1·kg-1비(24.04±5.21)ml·min-1·kg-1,P균<0.01],EH병LVH조적강저교비LVH조차이야유통계학의의(P<0.05).(3)경상관분석현시,EH병LVH조LVMI여VO2/kg정현저부상관(재AT치R=-0.40,재VO2max치R=-0.31,P<0.01).결론 EH환자심폐운동지표METs화VO2/kg강저,운동내량수손,병여LVMI증고상관.제시EH환자심장저비공능하강.
Objective To evaluate the cardiopulmonary exercise capacity in patients with essential hypertension (EH) complicating with or without left ventricular hypertrophy (LVH). Methods Graded maximal exercise test on the bicycle ergometer with respiratory gas analysis were performed in 30 gender and age matched normotensive controls, 40 EH patients without LVH and 30 EH patients with LVH (LVMI 125 g/m2 in males and 120 g/m2 in females). Metabolic equivalents (METs), oxygen uptake(VO2), oxygen uptake to body mass ratio (VO2/kg) and oxygen uptake to heart beat ratio (VO2/HR) at time of reaching anaerobic threshold (AT) and at maximal oxygen uptake (VO2max) were measured and compared. Results METs and VO2/kg were significantly reduced in EH patients with or without LVH compared with controls [ at AT, METs: 3.57±0. 8 and 4. 34±1.47 vs. 5.21±1.45 ; VO2/kg: 12. 38± 2. 85 and 14. 42±4. 33 vs. 18.48±4. 52, all P < 0. 01 ;at VO2max, METs:4.94±1.24 and 5. 90±1.51 vs. 6.96±1.85;VO2/kg:(17.20±4.34) ml·min-1·kg-1and (20.41±4.59 )ml · min-1·kg-1 vs. (24. 04±5.21) ml·min-1·kg-1, all P < 0. 01 ]. METs and VO2/kg at both time points were also significantly reduced in EH patients with LVH compared EH patients without LVH ( all P < 0. 05). The lower VO2/kg in hypertensive patients was significantly correlated to higher LVMI ( P < 0. 05 ). Conclusions Cardiopulmonary exercise capacity was reduced in hypertensive patients, especially in hypertensive patients with LVH.
