CAJ | 학술논문

目的观察复方倍他米松联合山莨菪碱注射治疗眉毛斑秃的疗效、安全性及患者满意度.方法 66例患者随机分为复方倍他米松组(A组)和复方倍他米松联合山莨菪碱组(B组),两组均按0.2 ml/cm2标准,从眉毛中央向两侧注射,每1个月注射1次,并观察疗效,3个月后根据不良事件发生率和患者的主观感受分析其安全性和满意度.结果 A组在治疗后1、2、3个月的有效率分别为31.25%、53.13%和71.88%,B组的有效率分别为58.82%、73.53%和88.23%,B组的疗效明显优于A组(P＜0.05);疗程结束后B组的不良事件发生率与A组相似(P＞0.05);B组的患者满意率为97.06%,高于A组的78.13%(P＜0.05).结论复方倍他米松注射液联合山莨菪碱注射液治疗眉毛斑秃较单独采用复方倍他米松可获得更好的疗效和满意度.
목적 관찰복방배타미송연합산랑탕감주사치료미모반독적료효、안전성급환자만의도.방법 66례환자수궤분위복방배타미송조(A조)화복방배타미송연합산랑탕감조(B조),량조균안0.2 ml/cm2표준,종미모중앙향량측주사,매1개월주사1차,병관찰료효,3개월후근거불량사건발생솔화환자적주관감수분석기안전성화만의도.결과 A조재치료후1、2、3개월적유효솔분별위31.25%、53.13%화71.88%,B조적유효솔분별위58.82%、73.53%화88.23%,B조적료효명현우우A조(P＜0.05);료정결속후B조적불량사건발생솔여A조상사(P＞0.05);B조적환자만의솔위97.06%,고우A조적78.13%(P＜0.05).결론 복방배타미송주사액연합산랑탕감주사액치료미모반독교단독채용복방배타미송가획득경호적료효화만의도.
Objective To observe the curative effect, safety and patient's satisfaction degree of combining compound betamethasone with anisodamine injection in the blocking treatment of eyebrow alopecia areata.Methods A total of 66 cases were randomly divined into two groups: patients were treated by compound betamethasone ( group A) and combining compound betamethasone with anisodamine ( group B). The drugs were injected from the middle of eyebrow alopecia areata to two sides by the standard of 0. 2 ml/cm2 in both groups one time a month. The curative effect of the all cases were observed at 1, 2 and 3 months after treatment. The safety of them were evaluated based on incidence rate of the side effect and their satisfactory degree were evaluated based on subjective reception 3 months after treatment. Results The effective rates in the group B were 58.82 %, 73.53 % and 88.23 % by turns at 1,2 and 3 months after treatment, and those in the group A were 31.25 %, 53.13 % and 71.88 %, respectively. The curative effect in the group B was better than that in the group A (P ＜ 0. 05), and the incidence rate of side effect in the group B was similar to that in the group A (P＞0.05) and the patient's satisfaction degree in group B was better than that in group A (P ＜0. 05) 3months after treatment. Conclusion The compound betamethasone combined with anisodamine injection in the treatment of eyebrow alopecia areata has superior curative efficacy, more safety and higher satisfactory degree in the patients.