临床与实验病理学杂志
臨床與實驗病理學雜誌
림상여실험병이학잡지
CHINESE JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2009年
6期
588-591
,共4页
杜娴娟%王立东%李吉林%王能超%焦新英%李学民%韩锁利
杜嫻娟%王立東%李吉林%王能超%焦新英%李學民%韓鎖利
두한연%왕립동%리길림%왕능초%초신영%리학민%한쇄리
食管肿瘤%贲门肿瘤%不典型增生%Rb
食管腫瘤%賁門腫瘤%不典型增生%Rb
식관종류%분문종류%불전형증생%Rb
esophageal neoplasms%cardia neoplasms%dysplasia%Rb
目的 探讨同一个体食管鳞状上皮不典型增生(esophageal epithelial dysplasia,EDYS)和贲门腺上皮不典型增生(gastric cardia dysplasia,GDYS)组织中Rb蛋白表达的变化特征及其意义.方法 采用免疫组化ABC法和组织病理学方法,分析河南食管癌高发区30例同一个体同时发生EDYS和GDYS组织中Rb蛋白的表达情况.结果 Rb在EDYS组织中阳性率为70%(21/30),GDYS组织阳性率为80%(24/30),两者阳性率差异无统计学意义(χ~2=0.800,P>0.05);同一个体EDYS和GDYS组织Rb表达有明显一致性(Kappa=0.561,P<0.01),25例(83%,25/30)同时出现EDYS和GDYS组织Rb表达的一致性改变,一致阳性率为67%(20/30),一致阴性率为17%(5/30);EDYS和GDYS组织中Rb的表达相关(P<0.01).结论 Rb在同一个体EDYS和GDYS组织中存在较高的表达一致性改变,进一步提示食管鳞癌和贲门腺癌可能具有相似的发病因素和分子机制.
目的 探討同一箇體食管鱗狀上皮不典型增生(esophageal epithelial dysplasia,EDYS)和賁門腺上皮不典型增生(gastric cardia dysplasia,GDYS)組織中Rb蛋白錶達的變化特徵及其意義.方法 採用免疫組化ABC法和組織病理學方法,分析河南食管癌高髮區30例同一箇體同時髮生EDYS和GDYS組織中Rb蛋白的錶達情況.結果 Rb在EDYS組織中暘性率為70%(21/30),GDYS組織暘性率為80%(24/30),兩者暘性率差異無統計學意義(χ~2=0.800,P>0.05);同一箇體EDYS和GDYS組織Rb錶達有明顯一緻性(Kappa=0.561,P<0.01),25例(83%,25/30)同時齣現EDYS和GDYS組織Rb錶達的一緻性改變,一緻暘性率為67%(20/30),一緻陰性率為17%(5/30);EDYS和GDYS組織中Rb的錶達相關(P<0.01).結論 Rb在同一箇體EDYS和GDYS組織中存在較高的錶達一緻性改變,進一步提示食管鱗癌和賁門腺癌可能具有相似的髮病因素和分子機製.
목적 탐토동일개체식관린상상피불전형증생(esophageal epithelial dysplasia,EDYS)화분문선상피불전형증생(gastric cardia dysplasia,GDYS)조직중Rb단백표체적변화특정급기의의.방법 채용면역조화ABC법화조직병이학방법,분석하남식관암고발구30례동일개체동시발생EDYS화GDYS조직중Rb단백적표체정황.결과 Rb재EDYS조직중양성솔위70%(21/30),GDYS조직양성솔위80%(24/30),량자양성솔차이무통계학의의(χ~2=0.800,P>0.05);동일개체EDYS화GDYS조직Rb표체유명현일치성(Kappa=0.561,P<0.01),25례(83%,25/30)동시출현EDYS화GDYS조직Rb표체적일치성개변,일치양성솔위67%(20/30),일치음성솔위17%(5/30);EDYS화GDYS조직중Rb적표체상관(P<0.01).결론 Rb재동일개체EDYS화GDYS조직중존재교고적표체일치성개변,진일보제시식관린암화분문선암가능구유상사적발병인소화분자궤제.
Purpose To characterize the alterations and significance of Rb in concurrent esophageal and gastric cardia precancerous lesions (dysplasia) from the same patients in Henan,a high-incidence area of esophageal carcinoma.Methods Rb protein expression was detected by the immunohistochemical staining (ABC method) in 30 patients with both esophageal and gastric cardia dysplasia in Henan area.Results Rb positive rates in esophageal epithelial dysplasia (EDYS) and gastric cardia dysplasia (GDYS) were 70% (21/30) and 80% (24/30), respectively, and the difference was not significant,(χ~2=0.800,P>0.05).However, there were 25 patients with Rb coincident changes in EDYS and GDYS from the same patient in 30 cases of esophageal and gastric cardia dysplasia (83%,25/30). The positive coincidence rate for Rb positive expression in EDYS and GDYS from the same patient accounted for 67% (20/30) and the negative coincidence rate was 17% (5/30) (Kappa=0.561,P<0.01).The significant relationship between Rb coincidence expression in EDYS and GDYS was found (P<0.01).Conclusions The high coincident alterations of Rb in EDYS and GDYS from the same patient indicate the possibility of similar molecular basis, which provides an important etiological clue for the similar geographic distribution and risk factors involved in esophageal squmaous cell carcinoma and gastric cardia adenocarcinoma.
