CAJ | 학술논문

目的:研究联合使用氨基葡聚糖和硫酸软骨素对大鼠和小鼠的抗炎镇痛效果及作用机制.方法:采用SD大鼠,于左后足趾中部皮下注射角叉菜胶建立足趾肿胀模型,对联合使用氨基葡聚糖和硫酸软骨素抗急性炎症疗效进行评价;将灭菌棉球植入大鼠两侧腹股沟皮下建立肉芽肿模型,进行抗慢性炎症疗效评价.采用ICR小鼠,腹腔注射0.6%醋酸溶液建立小鼠疼痛模型,对联合使用氨基葡聚糖和硫酸软骨素镇痛作用进行评价.结果:与正常对照组比较,联合使用氨基葡聚糖和硫酸软骨素可降低大鼠足趾肿胀度(P<0.05),联合使用氨基葡聚糖和硫酸软骨素可明显抑制大鼠内芽肿(P<0.01),联合使用氨基葡聚糖和硫酸软骨素可明显抑制醋酸致小鼠扭体次数(P<0.05).结论:联合使用氨基葡聚糖和硫酸软骨素,具有抗急性炎症及慢性炎症作用;可抑制醋酸致小鼠扭体反应次数,具有镇痛作用.
목적:연구연합사용안기포취당화류산연골소대대서화소서적항염진통효과급작용궤제.방법:채용SD대서,우좌후족지중부피하주사각차채효건립족지종창모형,대연합사용안기포취당화류산연골소항급성염증료효진행평개;장멸균면구식입대서량측복고구피하건립육아종모형,진행항만성염증료효평개.채용ICR소서,복강주사0.6%작산용액건립소서동통모형,대연합사용안기포취당화류산연골소진통작용진행평개.결과:여정상대조조비교,연합사용안기포취당화류산연골소가강저대서족지종창도(P<0.05),연합사용안기포취당화류산연골소가명현억제대서내아종(P<0.01),연합사용안기포취당화류산연골소가명현억제작산치소서뉴체차수(P<0.05).결론:연합사용안기포취당화류산연골소,구유항급성염증급만성염증작용;가억제작산치소서뉴체반응차수,구유진통작용.
Objective To investigate the anti-inflammatory and analgesic effects of combined application of glucosamine(GS)and chondroitin sulfate(CS).Methods The acute and chronic anti-inflammatory effects of combined application of GS and CS were observed respectively through carrageen-induced paw edema and cotton-induced inguinal granuloma of rats.The analgesic effect of combined application of GS and CS was investigated by the mouse pain model induced by 0.6% acetic acid Results As compared with the control group,the degree of paw edema and the weight of granuloma in combined application of GS and CS group were significantly reduced(P<0.05 and P<0.01,respectively);and the writhing number of mice decreased significantly(P<0.05).Conclusion Combined application of glucosamine and chondroitin sulfate demonstrates obviously anti-inflammatory and analgesic effects.