CAJ | 학술논문

凋亡素是一种来源于鸡贫血病毒的小分子蛋白,能够选择性地诱导肿瘤细胞和转化细胞的凋亡,而对正常细胞无作用.凋亡素的肿瘤细胞特异性与其在细胞中的核定位密切相关.它诱导的细胞凋亡既不依赖于p53,也不会被Bcl-2的过表达所抑制,但涉及Caspase-3的激活.因此,凋亡素可作为一种新型的肿瘤诊断工具和候选抗肿瘤治疗制剂.
조망소시일충래원우계빈혈병독적소분자단백,능구선택성지유도종류세포화전화세포적조망,이대정상세포무작용.조망소적종류세포특이성여기재세포중적핵정위밀절상관.타유도적세포조망기불의뢰우p53,야불회피Bcl-2적과표체소억제,단섭급Caspase-3적격활.인차,조망소가작위일충신형적종류진단공구화후선항종류치료제제.
Apoptin,a chicken anemia virus-derived protein.selectively induces apoptosis in trans-formed or tumor cells but not in normal cells.The tumor specificity of apoptin is thought to be related to its cel-lular localization.The apoptin-induced apoptosis is p53-independent and can not be blocked by overexpressionof Bcl-2.But activation of Caspase-3 is essential for apoptin-induced apoptosis.These features make apoptin a potential candidate as a novel therapeutic and diagnostic tool in cancer treatment.