中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
5期
665-666
,共2页
崔艳凤%陈立波%张长宁%黎丽萍%顾建芬%叶强
崔豔鳳%陳立波%張長寧%黎麗萍%顧建芬%葉彊
최염봉%진립파%장장저%려려평%고건분%협강
糖尿病%颈动脉内中膜厚度%搏波传导速度
糖尿病%頸動脈內中膜厚度%搏波傳導速度
당뇨병%경동맥내중막후도%박파전도속도
Diabetes mellitus%Intima-media thickness%Pulse wave velocity
目的 探讨糖尿病患者的颈动脉内中膜厚度(IMT)、脉搏波传导速度(PWV)的关系.方法 100例2型糖尿病患者随机分为:氢氯噻嗪组35例,缬沙坦组35例,缬沙坦联合氢氯噻嗪治疗组(联合组)30例,分别治疗16周,观察治疗前后各组收缩压(SBP)、舒张压(DBP)、24h尿白蛋白、血尿素氮(BUN)、颈动脉内中膜厚度(IMT)、脉搏波传导速度(PWV)、空腹血糖(FPG).结果 三组治疗前后SBP、DBP、24h尿白蛋白较治疗前比较有显著性差异(t=2.7875,2.755,2.733,2.645,均P＜0.05)；与IMT显著相关的因素依次有SBP(r=0.669,P=0.013)、脉压(r=0.581,P=0.015)、FPG(r=0.337,P=0.018).与PWV显著相关的因素依次有SBP(r=0.759,P=0.001)、脉压(r=0.707,P=0.002)、FPG(r=0.679,P=0.016).结论 PWV可作为评价2型糖尿病患者大动脉顺应性的无创指标.PWV的测量,对其血管并发症具有重要的临床价值.
目的 探討糖尿病患者的頸動脈內中膜厚度(IMT)、脈搏波傳導速度(PWV)的關繫.方法 100例2型糖尿病患者隨機分為:氫氯噻嗪組35例,纈沙坦組35例,纈沙坦聯閤氫氯噻嗪治療組(聯閤組)30例,分彆治療16週,觀察治療前後各組收縮壓(SBP)、舒張壓(DBP)、24h尿白蛋白、血尿素氮(BUN)、頸動脈內中膜厚度(IMT)、脈搏波傳導速度(PWV)、空腹血糖(FPG).結果 三組治療前後SBP、DBP、24h尿白蛋白較治療前比較有顯著性差異(t=2.7875,2.755,2.733,2.645,均P＜0.05)；與IMT顯著相關的因素依次有SBP(r=0.669,P=0.013)、脈壓(r=0.581,P=0.015)、FPG(r=0.337,P=0.018).與PWV顯著相關的因素依次有SBP(r=0.759,P=0.001)、脈壓(r=0.707,P=0.002)、FPG(r=0.679,P=0.016).結論 PWV可作為評價2型糖尿病患者大動脈順應性的無創指標.PWV的測量,對其血管併髮癥具有重要的臨床價值.
목적 탐토당뇨병환자적경동맥내중막후도(IMT)、맥박파전도속도(PWV)적관계.방법 100례2형당뇨병환자수궤분위:경록새진조35례,힐사탄조35례,힐사탄연합경록새진치료조(연합조)30례,분별치료16주,관찰치료전후각조수축압(SBP)、서장압(DBP)、24h뇨백단백、혈뇨소담(BUN)、경동맥내중막후도(IMT)、맥박파전도속도(PWV)、공복혈당(FPG).결과 삼조치료전후SBP、DBP、24h뇨백단백교치료전비교유현저성차이(t=2.7875,2.755,2.733,2.645,균P＜0.05)；여IMT현저상관적인소의차유SBP(r=0.669,P=0.013)、맥압(r=0.581,P=0.015)、FPG(r=0.337,P=0.018).여PWV현저상관적인소의차유SBP(r=0.759,P=0.001)、맥압(r=0.707,P=0.002)、FPG(r=0.679,P=0.016).결론 PWV가작위평개2형당뇨병환자대동맥순응성적무창지표.PWV적측량,대기혈관병발증구유중요적림상개치.
Objective To investigate the relationship between intima-media thickness(IMT)and pulse wave velocity(PWV)in patients with type 2 diabetes mellitus.Methods 100 cases with type 2 diabetes were randomly divided into:hydrochlorothiazide group of 35 cases,valsartan group of 35 cases,valsartan and hydrochlorothiazide combined treatment group(combined group)30 cases.All the patients were treated for 16 weeks,systolic blood pressure (SBP),diastolic blood pressure(DBP),24h urinary albumin,blood urea nitrogen(BUN),carotid IMT,PWV,fasting plasma glucose(FPG)were measured before and after treatment in each group.Results The SBP,DBP,24h urinary albumin before treatment compared with after treatment was significant differences in three groups(t =2.7875,2.755,2.733,2.645,all P ＜ 0.05); IMT associated with SBP(r =0.669,P =0.013),pulse pressure(r =0.581,P =0.015),FPG(r =0.337,P =0.018);PWV associated with SBP(r =0.759,P =0.001),pulse pressure(r =0.707,P=0.002),FPG(r =0.679,P =0.016).Conclusion The non-invasive indicators of PWV can be used as aortic compliance.The PWV measurement of its vascular complications has important clinical value.
