中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
7期
27-29
,共3页
张忠明%林治瓯%周新浪%郑祥
張忠明%林治甌%週新浪%鄭祥
장충명%림치구%주신랑%정상
心力衰竭,充血性%C反应蛋白质%肌钙蛋白I
心力衰竭,充血性%C反應蛋白質%肌鈣蛋白I
심력쇠갈,충혈성%C반응단백질%기개단백I
Heart failure,congestive%C- reactive protein%Troponin I
目的 探讨慢性心力衰竭患者高敏C反应蛋白(hs-CRP)和心肌肌钙蛋白I(cTnI)水平变化及其意义.方法 80例慢性心力衰竭患者(心力衰竭组)按NYHA心功能分级标准分为心功能Ⅲ级(40例)和心功能Ⅳ级(40例).另选择80例体检健康者作为对照组.监测心力衰竭组治疗前后hs-CRP和cTnI水平的变化,并与对照组进行比较.结果 心力衰竭组治疗前hs-CRP和cTnI水平[(11.56±2.72) mg/L、(0.46±0.11) μg/L]较对照组[(2.31±0.56) mg/L、(0.04±0.13)μg/L]明显升高,差异有统计学意义(P＜0.01)；心力衰竭组中心功能Ⅳ级患者hs-CRP和cTnI水平[(13.07±4.31) mg/L、(0.57±0.05) μg/L]较心功能Ⅲ级患者[(10.04±3.12) mg/L、(0.35±0.09)μg/L]明显升高,差异有统计学意义(P＜0.01).治疗后心功能Ⅲ级和心功能Ⅳ级患者hs-CRP和cTnI水平均较治疗前显著下降(P＜0.01).结论 慢性心力衰竭患者hs-CRP和cTnI水平升高,并且与心功能损害程度相关.hs-CRP和cTnI可能是反映慢性心力衰竭病情变化的有效指标.
目的 探討慢性心力衰竭患者高敏C反應蛋白(hs-CRP)和心肌肌鈣蛋白I(cTnI)水平變化及其意義.方法 80例慢性心力衰竭患者(心力衰竭組)按NYHA心功能分級標準分為心功能Ⅲ級(40例)和心功能Ⅳ級(40例).另選擇80例體檢健康者作為對照組.鑑測心力衰竭組治療前後hs-CRP和cTnI水平的變化,併與對照組進行比較.結果 心力衰竭組治療前hs-CRP和cTnI水平[(11.56±2.72) mg/L、(0.46±0.11) μg/L]較對照組[(2.31±0.56) mg/L、(0.04±0.13)μg/L]明顯升高,差異有統計學意義(P＜0.01)；心力衰竭組中心功能Ⅳ級患者hs-CRP和cTnI水平[(13.07±4.31) mg/L、(0.57±0.05) μg/L]較心功能Ⅲ級患者[(10.04±3.12) mg/L、(0.35±0.09)μg/L]明顯升高,差異有統計學意義(P＜0.01).治療後心功能Ⅲ級和心功能Ⅳ級患者hs-CRP和cTnI水平均較治療前顯著下降(P＜0.01).結論 慢性心力衰竭患者hs-CRP和cTnI水平升高,併且與心功能損害程度相關.hs-CRP和cTnI可能是反映慢性心力衰竭病情變化的有效指標.
목적 탐토만성심력쇠갈환자고민C반응단백(hs-CRP)화심기기개단백I(cTnI)수평변화급기의의.방법 80례만성심력쇠갈환자(심력쇠갈조)안NYHA심공능분급표준분위심공능Ⅲ급(40례)화심공능Ⅳ급(40례).령선택80례체검건강자작위대조조.감측심력쇠갈조치료전후hs-CRP화cTnI수평적변화,병여대조조진행비교.결과 심력쇠갈조치료전hs-CRP화cTnI수평[(11.56±2.72) mg/L、(0.46±0.11) μg/L]교대조조[(2.31±0.56) mg/L、(0.04±0.13)μg/L]명현승고,차이유통계학의의(P＜0.01)；심력쇠갈조중심공능Ⅳ급환자hs-CRP화cTnI수평[(13.07±4.31) mg/L、(0.57±0.05) μg/L]교심공능Ⅲ급환자[(10.04±3.12) mg/L、(0.35±0.09)μg/L]명현승고,차이유통계학의의(P＜0.01).치료후심공능Ⅲ급화심공능Ⅳ급환자hs-CRP화cTnI수평균교치료전현저하강(P＜0.01).결론 만성심력쇠갈환자hs-CRP화cTnI수평승고,병차여심공능손해정도상관.hs-CRP화cTnI가능시반영만성심력쇠갈병정변화적유효지표.
Objective To investigate the changes and values of serum high-sensitivity C-reactive protein (hs-CRP) and cardiac troponin I (cTnI) in patients with chronic heart failure.Methods Eighty patients with chronic heart failure (heart failure group) were divided into NYHA heart function Ⅲ grade ( 40 patients) and Ⅳ grade (40 patients).Eighty healthy people were included in control group.The levels of serum hs-CRP and cTnI were measured and compared.Results Before treatment,the levels of hs-CRP and cTnI in heart failure group [ ( 11.56 ± 2.72) mg/L,(0.46 ± 0.11 ) μ g/L] were significantly higher than those in control group [ (2.31 ± 0.56) mg/L,(0.04 ± 0.13 ) μg/L ] (P ＜ 0.01 ).The levels of hs-CRP and cTnI in heart function Ⅳ grade patients [ ( 13.07 ± 4.31 ) mg/L,(0.57 ± 0.05 ) μg/L] were significantly higher than those in heart function Ⅲ grade patients [(10.04 ±3.12) mg/L,(0.35 ±0.09) μg/L](P＜0.01).After treatment,the levels of hs-CRP and cTnI in heart function Ⅲ grade and Ⅳ grade patients were significantly decreased compared with those before treatment(P＜ 0.01 ).Conclusions The levels of hs-CRP and cTnI in chronic heart failure patients are related to the inflammatory activities and myocardial damage.hs-CRP and cTnI may be effective factors to reflect the severity of heart failure.
