CAJ | 학술논문

目的探讨机械通气对重症肺炎患者尿微量白蛋白水平的影响.方法采用机械通气治疗的78例重症肺炎患者,治疗72 h内动态检测尿微量白蛋白(MAU)与尿肌酐(CR)比值(ACR)MAU/CR,以ACR值25 mg/mmol为临界值,分为ACR增多组与未增多组,观察两组MAU水平的动态变化,以评估与预后的关系.结果重症肺炎78例中,入院72 h MUA水平增高64例(占82.1%),其中ACR增高组46例,ACR未增高组18例.两组APACHEⅡ评分、CPIS评分、降钙素原、2周内脱机成功率和病死率比较差异均有统计学意义(t=3.50、2.19、x~2=3.95、6.70、5.38,P=0.01,0.03,0.04,0.01,0.02,均P＜0.05).结论机械通气治疗重症肺炎患者MAU水平检测对评估预后有重要的临床意义.
목적 탐토궤계통기대중증폐염환자뇨미량백단백수평적영향.방법 채용궤계통기치료적78례중증폐염환자,치료72 h내동태검측뇨미량백단백(MAU)여뇨기항(CR)비치(ACR)MAU/CR,이ACR치25 mg/mmol위림계치,분위ACR증다조여미증다조,관찰량조MAU수평적동태변화,이평고여예후적관계.결과 중증폐염78례중,입원72 h MUA수평증고64례(점82.1%),기중ACR증고조46례,ACR미증고조18례.량조APACHEⅡ평분、CPIS평분、강개소원、2주내탈궤성공솔화병사솔비교차이균유통계학의의(t=3.50、2.19、x~2=3.95、6.70、5.38,P=0.01,0.03,0.04,0.01,0.02,균P＜0.05).결론 궤계통기치료중증폐염환자MAU수평검측대평고예후유중요적림상의의.
Objective To evaluate the clinical significance of the changes of microalbunminuria(MAU) levels in mechanical ventilated patients with severe pneumonia. Methods According to the ratio between the microalbunminuria and the urine creatinine (MAU/CR) (ACR), setting 25mg/mmol as the threshold, 78 mechanical ventilated patients with severe pneumonia were divided into two groups :ACR increasing group and ACR Non-increasing group,then the clinical significance of changes of MAU levels in 72 hours on prognosis of these patients was observed. Results MAU increased in 64 cases(82. 1%) ,of which 46 cases in ACR increasing group and 18 cases in ACR non-increasing group. There showed statistically significant differences on APACHE Ⅱ score, CPIS score,PCT、the success of getting out of mechanical ventilation and the mortality between two groups, (t = 3.50、2. 19 、x~2 = 3. 95、6. 70、5.38 ,P = 0.01,0.03,0.04,0.01,0.02, all P ＜ 0.05). Conclusion Changes of MAU levels have the clinical significance on prognosis of the mechanical ventilated patients with severe pneumonia.