CAJ | 학술논문

目的研究血管内皮生长因子(VEGF)在乳腺癌中的表达及临床意义.方法应用S-P免疫组化方法检测60例乳腺癌组织(乳腺癌组)和20例乳腺良性病变组织(乳腺纤维腺瘤组)中VEGF的表达情况,结合临床及病理形态学资料进行统计分析.结果乳腺癌组中VEGF阳性表达49例；乳腺纤维腺瘤组中VEGF阳性表达4例；2组VEGF阳性率比较差异有统计学意义(81.67％与20.00％,u=4.39,P=0.000).VEGF的表达与淋巴结转移、肿瘤大小、组织学分级和临床分期呈正相关(rs =0.357、0.594、0.680、0.540,P均＜0.05),与患者年龄、雌激素、孕激素受体情况无相关性(P均＞0.05).结论 VEGF可能与乳腺癌的进展、转移及预后有关,作为独立的指标对判定预后具有参考意义.
목적 연구혈관내피생장인자(VEGF)재유선암중적표체급림상의의.방법 응용S-P면역조화방법검측60례유선암조직(유선암조)화20례유선량성병변조직(유선섬유선류조)중VEGF적표체정황,결합림상급병리형태학자료진행통계분석.결과 유선암조중VEGF양성표체49례；유선섬유선류조중VEGF양성표체4례；2조VEGF양성솔비교차이유통계학의의(81.67％여20.00％,u=4.39,P=0.000).VEGF적표체여림파결전이、종류대소、조직학분급화림상분기정정상관(rs =0.357、0.594、0.680、0.540,P균＜0.05),여환자년령、자격소、잉격소수체정황무상관성(P균＞0.05).결론 VEGF가능여유선암적진전、전이급예후유관,작위독립적지표대판정예후구유삼고의의.
Objective To study the expression of vascular endothelial growth factor(VEGF) in breast cancer and its clinical significance.Methods The expression of the protein was determined by immunohistochemistry in 60 cases of breast cancer and 20 cases of benign breast diseases.The relationship of VEGF expression with clinicopathological characteristics was statistically analyzed.Results Of all the 60 cases of breast cancers,49 cases showed positive VEGF expression,while only 4 cases expressed VEGF in the group of breast adenofibroma.There was significant difference between breast cancer and breast adenofibroma( P ＜ 0.05 ).The overexpression of VEGF was related with the tumor size ( P ＜ 0.05 ),histological grade ( P ＜ 0.05 ),lymph node state ( P ＜ 0.05 ) and TNM stage ( P ＜ 0.05 ),but was irrelevant to age,ER and PR( P ＞ 0.05).Conclusion VEGF might have important significance in the development,metastasis and prognosis of human breast cancer.It may be taken as an independent marker to predict the prognosis of breast cancer.