中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2011年
1期
68-70
,共3页
葛建杰%王沫学%高夕宁%赵玉新
葛建傑%王沫學%高夕寧%趙玉新
갈건걸%왕말학%고석저%조옥신
光学相干断层扫描成像%脉络膜新生血管化%吲哚青绿%荧光血管造影术%光化学疗法
光學相榦斷層掃描成像%脈絡膜新生血管化%吲哚青綠%熒光血管造影術%光化學療法
광학상간단층소묘성상%맥락막신생혈관화%신타청록%형광혈관조영술%광화학요법
Optical coherence tomography%Choroidal neovascularization%Indocyanine green%Fluoreseein angiography%Photochemotherapy
目的 探讨光学相干断层扫描(optical coherence tomography,OCT)对光动力疗法(photodynamic terapy PDT)治疗中心性渗出性脉络膜视网膜病变(central exudative chorioretinopathy,CEC)脉络膜新生血管(choroidal neovascularization,CNV)的临床应用价值.方法 对CEC患者45例(46只眼)进行光学相干断层扫描,荧光素眼底血管造影(fundus fluorescein angiography,FFA),吲哚青绿脉络膜血管造影(indocyanine green angiography,ICGA)检查.根据FFA,ICGA和OCT检查结果,明确CNV位置、范围和大小.PDT治疗按维替泊芬PDT治疗(VIP)研究组的方法 进行.并对其疗效进行评价.结果 光动力疗法(PDT)治疗后视力提高者13只眼,占28.26%;视力稳定不变者22只眼,占47.82%;视力下降者11只眼,占23.92%.OCT复查结果 为14只眼(3044%)黄斑水肿消失;18只眼(39.13%)黄斑水肿减轻;10只眼(21.73%)无变化;4只眼(8.7%)黄斑冰肿加重.CNV消失15只眼(32.61%),CNV缩小24只眼(52.17%),CNV无变化4只眼(8.7%),CNV增大3只眼(6.52%).治疗后视网膜厚度明显变薄(P<0.01).黄斑中心凹视网膜神经上皮层厚度与视力呈负相关(r=0.4963,P<0.01).结论 OCT可客观、精确地显示CNV的位置、大小、范围及视网膜水肿的变化程度,对指导光动力疗法(PDT)治疗中心性渗出性脉络膜视网膜病变(CEC)脉络膜新生血管(CNV)的疗效评价有着重要价值.
目的 探討光學相榦斷層掃描(optical coherence tomography,OCT)對光動力療法(photodynamic terapy PDT)治療中心性滲齣性脈絡膜視網膜病變(central exudative chorioretinopathy,CEC)脈絡膜新生血管(choroidal neovascularization,CNV)的臨床應用價值.方法 對CEC患者45例(46隻眼)進行光學相榦斷層掃描,熒光素眼底血管造影(fundus fluorescein angiography,FFA),吲哚青綠脈絡膜血管造影(indocyanine green angiography,ICGA)檢查.根據FFA,ICGA和OCT檢查結果,明確CNV位置、範圍和大小.PDT治療按維替泊芬PDT治療(VIP)研究組的方法 進行.併對其療效進行評價.結果 光動力療法(PDT)治療後視力提高者13隻眼,佔28.26%;視力穩定不變者22隻眼,佔47.82%;視力下降者11隻眼,佔23.92%.OCT複查結果 為14隻眼(3044%)黃斑水腫消失;18隻眼(39.13%)黃斑水腫減輕;10隻眼(21.73%)無變化;4隻眼(8.7%)黃斑冰腫加重.CNV消失15隻眼(32.61%),CNV縮小24隻眼(52.17%),CNV無變化4隻眼(8.7%),CNV增大3隻眼(6.52%).治療後視網膜厚度明顯變薄(P<0.01).黃斑中心凹視網膜神經上皮層厚度與視力呈負相關(r=0.4963,P<0.01).結論 OCT可客觀、精確地顯示CNV的位置、大小、範圍及視網膜水腫的變化程度,對指導光動力療法(PDT)治療中心性滲齣性脈絡膜視網膜病變(CEC)脈絡膜新生血管(CNV)的療效評價有著重要價值.
목적 탐토광학상간단층소묘(optical coherence tomography,OCT)대광동력요법(photodynamic terapy PDT)치료중심성삼출성맥락막시망막병변(central exudative chorioretinopathy,CEC)맥락막신생혈관(choroidal neovascularization,CNV)적림상응용개치.방법 대CEC환자45례(46지안)진행광학상간단층소묘,형광소안저혈관조영(fundus fluorescein angiography,FFA),신타청록맥락막혈관조영(indocyanine green angiography,ICGA)검사.근거FFA,ICGA화OCT검사결과,명학CNV위치、범위화대소.PDT치료안유체박분PDT치료(VIP)연구조적방법 진행.병대기료효진행평개.결과 광동력요법(PDT)치료후시력제고자13지안,점28.26%;시력은정불변자22지안,점47.82%;시력하강자11지안,점23.92%.OCT복사결과 위14지안(3044%)황반수종소실;18지안(39.13%)황반수종감경;10지안(21.73%)무변화;4지안(8.7%)황반빙종가중.CNV소실15지안(32.61%),CNV축소24지안(52.17%),CNV무변화4지안(8.7%),CNV증대3지안(6.52%).치료후시망막후도명현변박(P<0.01).황반중심요시망막신경상피층후도여시력정부상관(r=0.4963,P<0.01).결론 OCT가객관、정학지현시CNV적위치、대소、범위급시망막수종적변화정도,대지도광동력요법(PDT)치료중심성삼출성맥락막시망막병변(CEC)맥락막신생혈관(CNV)적료효평개유착중요개치.
Objective To verify the applicable significance of optical coherence tomography (OCT)photodynamic therapy (PDT) for central exudative chorioretinopathy (CEC) choroidal neovascularization (CNV). Methods Forty-five cases (46 eyes) of central exudative chorioretinopathy (CEC) were managed with PDT. Before and post-treatment, all cases underwent OCT, fiuorescein angiography (FFA) and indocyanine green angiography (ICGA). PDT treatment was in accordance with the PDT verteporfin therapy (VIP) Study Group methods. Results The visual acuities of last visit were compared with those before the treatment. The visual acuity was improved in 13eyes (28.26%), unchanged in 22 eyes (47.82%), and declined in 11 eyes (23.92%). OCT was re-done and compared with OCT images before PDT treatment. The macular edema was disappeared in 14 eyes (30.44%), decreased in 18 eyes (39.13%), unchanged in 10 eyes (21.73%), and increased in 4 eyes (8.7%). CNV was disappeared or decreased in 39 eyes (84.78%), unchanged in 4 eyes (8.7%),and progressed in 3 eyes (6.52%). The retinal thickness was decreased obviously (P ＜0.001). The statistical analysis showed there was a negative correlation between the thickness of fovea and visual acuity (r =0.4963, P =0.001). Conclusions OCT can precisely show the location, size and changes of retinal thickness and has an important significance in PDT treatment for CEC.
