CAJ | 학술논문

目的探讨民航飞行员的胱氨酸蛋白酶抑制剂C(Cys C)水平及其与血糖血脂之间的关系. 方法 287名参加例行体检的男性飞行员(平均年龄为39.6±8.3岁),纳入本次研究,分别测定其空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及Cys C水平.对所得结果进行统计学分析. 结果血脂代谢紊乱及空腹血糖受损的民航飞行员血清Cys C水平较正常组显著增高(P<0.01);Cys C水平与年龄无显著相关;随着脂代谢紊乱程度的增加,Cys C呈显著增高趋势(F=5.80～11.26,P<0.01);Pearson相关分析结果显示,Cys C与TG、HDL、LDL及FBG存在显著相关(P<0.05);多因素回归分析显示,TG、HDL-C、LDL-C、FBG水平是CysC水平的显著影响因素(P<0.05). 结论 Cys C水平与民航飞行员的糖、脂代谢紊乱等心血管疾病(CVD)危险因素显著相关,未来可能作为此类人群CVD发病危险评估及预警的重要指标,为飞行安全提供保障.
목적 탐토민항비행원적광안산단백매억제제C(Cys C)수평급기여혈당혈지지간적관계. 방법 287명삼가례행체검적남성비행원(평균년령위39.6±8.3세),납입본차연구,분별측정기공복혈당(FBG)、총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)급Cys C수평.대소득결과진행통계학분석. 결과 혈지대사문란급공복혈당수손적민항비행원혈청Cys C수평교정상조현저증고(P<0.01);Cys C수평여년령무현저상관;수착지대사문란정도적증가,Cys C정현저증고추세(F=5.80～11.26,P<0.01);Pearson상관분석결과현시,Cys C여TG、HDL、LDL급FBG존재현저상관(P<0.05);다인소회귀분석현시,TG、HDL-C、LDL-C、FBG수평시CysC수평적현저영향인소(P<0.05). 결론 Cys C수평여민항비행원적당、지대사문란등심혈관질병(CVD)위험인소현저상관,미래가능작위차류인군CVD발병위험평고급예경적중요지표,위비행안전제공보장.
Objective To investigate the relationship between the levels of serum Cystatin C (Cys C) and fasting blood glucose (FBG) and lipid profiles in Chinese civil pilot. Methods Two hundred and eight-seven pilots of Civil Aviation Administration of China (Male, 39.6±8.3 yrs) were involved in the study by taking the chance of their regular physical examination. The levels of FBG, lipid profiles and Cys C were measured for final statistic analysis. Results Cys C levels of the pilots with dyslipidemia and injured glucose tolerance were significantly higher than that in normal group (P ～0.01). Cys C level was insignificantly correlated with age. Furthermore Cys C showed an increasing tendency with the deterioration of lipid metabolism (F= 5.80-11.26, P< 0.01). The multiple linear regression analysis showed that triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and FBG were the significant influence factors against Cys C. Conclusions There is a significant correlation between Cys C level and the risk factors of cardiovascular disease. Therefore it might be taken as a potential predictive marker for judging cardiovascular events of pilot.