CAJ | 학술논문

目的探讨黄芪注射液早期干预对重度窒息新生儿脑损伤程度的影响.方法重度窒息复苏后的新生儿80例,依入院顺序单双号分为常规治疗组(对照组)40例和黄芪注射液治疗组(治疗组)40例,对照组在对症支持处理的基础上使用脑活素和胞二磷胆碱治疗;治疗组在常规治疗基础上尽早(生后6 h内)应用黄芪注射液治疗.观察和比较2组惊厥发生率和病死率,缺氧缺血性脑病(HIE)的临床分度和行为神经评分测定.结果治疗组惊厥的发生率明显低于对照组(45.00%与67.50%,χ24.501,P<0.05);生后7～8 d和12～14 d的行为评分<35分者所占百分比,前者亦明显低于后者(48.57%与74.19%,χ24.642,P<0.05;31.42%与58.06%,χ24.601,P<0.05),2组病死率差异无统计学意义(12.50%与22.50%,χ22.000,P>0.05).结论重度窒息新生儿,在对症支持治疗基础上尽早使用黄芪注射液,能显著减轻缺氧缺血性脑损伤程度.
목적 탐토황기주사액조기간예대중도질식신생인뇌손상정도적영향.방법 중도질식복소후적신생인80례,의입원순서단쌍호분위상규치료조(대조조)40례화황기주사액치료조(치료조)40례,대조조재대증지지처리적기출상사용뇌활소화포이린담감치료;치료조재상규치료기출상진조(생후6 h내)응용황기주사액치료.관찰화비교2조량궐발생솔화병사솔,결양결혈성뇌병(HIE)적림상분도화행위신경평분측정.결과 치료조량궐적발생솔명현저우대조조(45.00%여67.50%,χ24.501,P<0.05);생후7～8 d화12～14 d적행위평분<35분자소점백분비,전자역명현저우후자(48.57%여74.19%,χ24.642,P<0.05;31.42%여58.06%,χ24.601,P<0.05),2조병사솔차이무통계학의의(12.50%여22.50%,χ22.000,P>0.05).결론중도질식신생인,재대증지지치료기출상진조사용황기주사액,능현저감경결양결혈성뇌손상정도.
Objective To observe the effects of early intravenous administration of Astragalus on brain inju-ry in neonates with severe asphyxia. Methods According to hospital serial number, 80 neonates with severe as-phyxia were divided into conventional treatment group (control group) (n=40), which was on the basis of symp-tomatic support treatment for the use of cerebrolysin and citicoline treatment; Astragalus injection treatment group (n=40), which, apart from the conventional treatment, Astragalus injection was given as soon as possible (within six hours after birth). The incidence of convulsions or frequent seizures convulsions and the mortality in two groups, the clinical degree of hypoxic ischemic encephalopathy (HIE) and the behavior nerve score determination were ob-served and compared. Results The incidence of convulsions or frequent seizures convulsions was significantly lower in the Astragalus treatment group than in the control group (45.00% vs 67.50%, χ24.501,P<0.05). The per-centage of the behavior nerve score determination in 7 d-8d and 12 d-14d after birth was obviously lower in the for-mer group than the latter one (48.57% vs 74.19%, χ2 4.642,P<0.05; 31.42% vs 58.06%, χ24.601, P<0.05). The mortality was not significant different between the two groups (12.50 % vs 22.50%, χ22.000, P>0.05). Conclusion For severe asphyxia neonates, on the basis of the symptomatic support treatment, the use of Astragalus injection, as soon as possible, can significantly reduce the hypoxic ischemic brain injury.