中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
2012年
2期
153-155
,共3页
孙广莉%苏刚%朱豫%郝尚臣
孫廣莉%囌剛%硃豫%郝尚臣
손엄리%소강%주예%학상신
视神经炎/治疗%钴胺酰胺类/治疗应用%糖皮质激素类/治疗应用%治疗结果
視神經炎/治療%鈷胺酰胺類/治療應用%糖皮質激素類/治療應用%治療結果
시신경염/치료%고알선알류/치료응용%당피질격소류/치료응용%치료결과
Optic neuritis/therapy%Cobamides/therapeutic use%Glucocorticoids/therapeutic use%Treatment outcome
目的 观察甲钴胺联合糖皮质激素治疗视神经炎的临床疗效.方法 回顾性研究.临床确诊为视神经炎的74例患者118只眼纳入研究.其中,视神经乳头炎38例55只眼,球后视神经炎36例63只眼.将患者按随机对照原则分为治疗组和对照组,分别为37例59只眼.治疗组给予半球后注射甲钴胺注射液500 μg/次,1次/d,10次为1个疗程；2～3个疗程后改口服甲钴胺500 μg/次,3次/d.全身静脉滴注地塞米松15mg/d,1周后改为强的松龙30 mg/d口服,每5天减量,每次减量5 mg,同时口服维生素B110 mg,3次/d,使用能量合剂、血管扩张剂.对照组除不使用甲钴胺外,其余治疗同治疗组.对比分析两组患者治疗后的疗效差异.结果 治疗组59只眼中,显效42只眼,占71.19％；有效15只眼,占25.42％；无效2只眼,占3.39％.其总有效率为96.61％.对照组59只眼中,显效30只眼,占50.85％;有效26只眼,占44.07％；无效3只眼,5.08％.其总有效率为94.92％.两组总有效率比较,差异无统计学意义(x2=1.10,P＞0.05)；显效率比较,差异有统计学意义(x2=5.65,P＜0.05).结论 甲钴胺联合糖皮质激素可有效治疗视神经炎.
目的 觀察甲鈷胺聯閤糖皮質激素治療視神經炎的臨床療效.方法 迴顧性研究.臨床確診為視神經炎的74例患者118隻眼納入研究.其中,視神經乳頭炎38例55隻眼,毬後視神經炎36例63隻眼.將患者按隨機對照原則分為治療組和對照組,分彆為37例59隻眼.治療組給予半毬後註射甲鈷胺註射液500 μg/次,1次/d,10次為1箇療程；2～3箇療程後改口服甲鈷胺500 μg/次,3次/d.全身靜脈滴註地塞米鬆15mg/d,1週後改為彊的鬆龍30 mg/d口服,每5天減量,每次減量5 mg,同時口服維生素B110 mg,3次/d,使用能量閤劑、血管擴張劑.對照組除不使用甲鈷胺外,其餘治療同治療組.對比分析兩組患者治療後的療效差異.結果 治療組59隻眼中,顯效42隻眼,佔71.19％；有效15隻眼,佔25.42％；無效2隻眼,佔3.39％.其總有效率為96.61％.對照組59隻眼中,顯效30隻眼,佔50.85％;有效26隻眼,佔44.07％；無效3隻眼,5.08％.其總有效率為94.92％.兩組總有效率比較,差異無統計學意義(x2=1.10,P＞0.05)；顯效率比較,差異有統計學意義(x2=5.65,P＜0.05).結論 甲鈷胺聯閤糖皮質激素可有效治療視神經炎.
목적 관찰갑고알연합당피질격소치료시신경염적림상료효.방법 회고성연구.림상학진위시신경염적74례환자118지안납입연구.기중,시신경유두염38례55지안,구후시신경염36례63지안.장환자안수궤대조원칙분위치료조화대조조,분별위37례59지안.치료조급여반구후주사갑고알주사액500 μg/차,1차/d,10차위1개료정；2～3개료정후개구복갑고알500 μg/차,3차/d.전신정맥적주지새미송15mg/d,1주후개위강적송룡30 mg/d구복,매5천감량,매차감량5 mg,동시구복유생소B110 mg,3차/d,사용능량합제、혈관확장제.대조조제불사용갑고알외,기여치료동치료조.대비분석량조환자치료후적료효차이.결과 치료조59지안중,현효42지안,점71.19％；유효15지안,점25.42％；무효2지안,점3.39％.기총유효솔위96.61％.대조조59지안중,현효30지안,점50.85％;유효26지안,점44.07％；무효3지안,5.08％.기총유효솔위94.92％.량조총유효솔비교,차이무통계학의의(x2=1.10,P＞0.05)；현효솔비교,차이유통계학의의(x2=5.65,P＜0.05).결론 갑고알연합당피질격소가유효치료시신경염.
Objective To observe the efficacy of glucocorticoid and Mecobalamin in the treatment of optic neuritis.Methods Seventy-four patients (118 eyes) with optic neuritis were enrolled in this study.There were 38 patients (55 eyes) with optic nerve papillitis,36 patients (63 eyes) with retrobulbar neuritis.The patients were divided into treatment and control group,37 patients (59 eyes) in each group.The treatment group received semi-retrobulbar injection of 500μg Mecobalamin per day,10 times for one course; after two to three courses changed oral 500 μg Mecobalamin,three times per day.Systemic intravenous injection of 15 dexamethasone mg per day for one week,then prednisolone 30 mg per day orally,the dosage was reduced every five days for 5 mg; oral administration of vitamin B1,10 mg three times per day,use of energy mixture,vasodilators.Control group underwent the same therapy as the treatment group without Mecobalamin.The efficacy differences between two groups were comparatively analyzed.Results Among 59 eyes in the treatment group,42 eyes (71.19％) were markedly effective,15 eyes (25.42％) were valid and two eyes (3.39％) were invalid.The total effective rate was 96.61％.Among 59 eyes in the control group,30 eyes (50.85％) were markedly effective,26 eyes (44.07％) were valid and three eyes (5.08％) were invalid.The total effective rate was 94.92 ％.The difference of total effective rate between two groups was not statistically significant (x2 =1.10,P＞0.05) ; but there was a difference in markedly effective ratebetween two groups (x2 =5.65,P＜0.05).Conclusion Mecobalamin combined with glucocorticoids was effective in the treatment of optic neuritis.
