南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2009年
7期
1397-1399
,共3页
获得性免疫缺陷综合征%胃镜检查%幽门螺杆菌%胃粘膜
穫得性免疫缺陷綜閤徵%胃鏡檢查%幽門螺桿菌%胃粘膜
획득성면역결함종합정%위경검사%유문라간균%위점막
acquired immune deficiency syndome%endoscopy%Helicobacter pylori%gastric mucosa
目的 分析HIV/AIDS临床各期患者胃粘膜幽门螺杆菌(Hp)感染情况,探讨其发生的机制.方法 HIV/AIDS临 床各期患者170例,对照组为普通患者(HW阴性)34例,均行胃镜检查,并对活检粘膜行快速尿素酶及病理检测明确有无Hp感染.结果 各组Hp检出率分别为无症状HIV感染期(A1、A2)23.4%(11/47例),有症状感染期(B1、B2)14.0%(8/57例),AIDS期(A3、B3、C1-3)13.6%(9/66例),对照组47.1%(16/34).HIV/AIDS各组Hp检出率低于对照组,有症状感染期(B1、B2)组和AIDS期(A3、B3、C1-3)组均低于无症状HIV感染期(A1、A2)组,差异均有统计学意义(P<0.05).结论 在HW/AIDS临床各期患者中,胃粘膜严重的免疫缺陷,可能导致Hp感染率下降.
目的 分析HIV/AIDS臨床各期患者胃粘膜幽門螺桿菌(Hp)感染情況,探討其髮生的機製.方法 HIV/AIDS臨 床各期患者170例,對照組為普通患者(HW陰性)34例,均行胃鏡檢查,併對活檢粘膜行快速尿素酶及病理檢測明確有無Hp感染.結果 各組Hp檢齣率分彆為無癥狀HIV感染期(A1、A2)23.4%(11/47例),有癥狀感染期(B1、B2)14.0%(8/57例),AIDS期(A3、B3、C1-3)13.6%(9/66例),對照組47.1%(16/34).HIV/AIDS各組Hp檢齣率低于對照組,有癥狀感染期(B1、B2)組和AIDS期(A3、B3、C1-3)組均低于無癥狀HIV感染期(A1、A2)組,差異均有統計學意義(P<0.05).結論 在HW/AIDS臨床各期患者中,胃粘膜嚴重的免疫缺陷,可能導緻Hp感染率下降.
목적 분석HIV/AIDS림상각기환자위점막유문라간균(Hp)감염정황,탐토기발생적궤제.방법 HIV/AIDS림 상각기환자170례,대조조위보통환자(HW음성)34례,균행위경검사,병대활검점막행쾌속뇨소매급병리검측명학유무Hp감염.결과 각조Hp검출솔분별위무증상HIV감염기(A1、A2)23.4%(11/47례),유증상감염기(B1、B2)14.0%(8/57례),AIDS기(A3、B3、C1-3)13.6%(9/66례),대조조47.1%(16/34).HIV/AIDS각조Hp검출솔저우대조조,유증상감염기(B1、B2)조화AIDS기(A3、B3、C1-3)조균저우무증상HIV감염기(A1、A2)조,차이균유통계학의의(P<0.05).결론 재HW/AIDS림상각기환자중,위점막엄중적면역결함,가능도치Hp감염솔하강.
Objective To analyze Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in difierent clinical stages.Methods This study involved 170 patients with HIV/AIDS and 34 HIV-negative patients.All the patients underwent upper endoscopy and antral gastric biopsy to determine the status of Helieobaeter pylori infection using aniline red staining and rapid urease test.The patients with HIV/AIDS were stratified based on CD4~+T lymphocyte counts and clinical setting into asymptomatic HIV infection(A1,A2)group,symptomatic HIV infection(B1,B2)group and AIDS(A3,B3,C1-3)group.Results The prevalence of Helicobacter pylori infection in HIV/AIDS patients was 16.5%(28/170),and in the 3 groups classified,the infection rates were 23.4%(11/47),14.0%(8/57),and 13.6%(9/66),respectively;the infection rate was 47.1%(16/34) in the control group.Helicobacter pylori infection rate in the gastric mucosa of the patients with HIV/AIDS in different clinical stages was significantly lower than that of the control group (P<0.05);the infection rates in symptomatic HIV-infected(B1,B2)group and AIDS(A3,B3,C1-3)group were significantly lower than that in asymptomatic HIV-infected (A1,A2)group(P<0.05).Conclusion The low Helicobacter priori infection rate in HIV/AIDS patients may result from severe immunodeficiency in the gastric mucosa.
