中国医药工业杂志
中國醫藥工業雜誌
중국의약공업잡지
CHINESE JOURNAL OF PHARMACEUTICALS
2010年
2期
141-147
,共7页
A40926%生物合成%结构修饰%达巴万星%综述
A40926%生物閤成%結構脩飾%達巴萬星%綜述
A40926%생물합성%결구수식%체파만성%종술
A40926%biosynthesis%structural modification%dalbavancin%review
综述了继替考拉宁之后的第二代半合成糖肽类抗生素达巴万星前体A40926的研究进展,包括其结构、发酵生产、生物合成以及结构修饰.重点阐述了A40926的生物合成基因簇以及合成途径.达巴万星是A40926的半合成化合物,目前处于Ⅲ期临床研究,它具有比万古霉索和替考拉宁更强的生物活性.
綜述瞭繼替攷拉寧之後的第二代半閤成糖肽類抗生素達巴萬星前體A40926的研究進展,包括其結構、髮酵生產、生物閤成以及結構脩飾.重點闡述瞭A40926的生物閤成基因簇以及閤成途徑.達巴萬星是A40926的半閤成化閤物,目前處于Ⅲ期臨床研究,它具有比萬古黴索和替攷拉寧更彊的生物活性.
종술료계체고랍저지후적제이대반합성당태류항생소체파만성전체A40926적연구진전,포괄기결구、발효생산、생물합성이급결구수식.중점천술료A40926적생물합성기인족이급합성도경.체파만성시A40926적반합성화합물,목전처우Ⅲ기림상연구,타구유비만고매색화체고랍저경강적생물활성.
It was reviewed that the recent advance on A40926,a precursor of a second-generation glycopeptides antibiotic,dalbavancin,developed after teicoplanin,including the structure,fermentation production,biosynthesis and structural modification of A40926.The biosynthesis gene clusters and synthetic route of A40926 were especially introduced.Dalbavancin,a novel semisynthetic derivative of A40926,showing more potent than vancomycin and teicoplanin,is now in the phase Ⅲ clinical trials.
